Distribution of Group-specific Components (Gc) in the Sera of Native Africans
Distribution of Group-specific Components (Gc) in the Sera of Native Africans
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DOI：
10.1038/192766a0
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发表时间：
1961-11
期刊：
影响因子：
64.8
通讯作者：
J. Hirschfeld;J. Sonnet
中科院分区：
文献类型：
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作者：
J. Hirschfeld;J. Sonnet
血清的组特异性成分由可通过免疫电泳法显示的可变的α-2球蛋白组成。该系统允许将人血清分成三种定性不同的模式，其特征是存在快速移动的组特异性成分(Gc1-1)、慢移动的成分(GC2-2)，在免疫电泳中这两种成分都会产生正常的弧形沉淀，或者同时存在快移动和慢移动的成分(GC2-1)，这是由于免疫电泳中这些不同但免疫相同的快移动和慢移动的成分之间的免疫同一性反应而产生的延伸的双峰沉淀1。对42个有137个孩子的家庭和600多个母子组合的调查表明，这些血清型是由两个无显性的常染色体等位基因(Gc1和Gc2)决定的，其中Gc1-1和Gc2-2为纯合子，Gc2-1为杂合子。到目前为止，在所调查的材料中还没有发现这一遗传学理论的例外情况或尚未解决的分型困难。
THE group-specific components of sera consist of electrophoretically variable α2-globulins demonstrable by means of an immuno-electrophoretic technique1. This system allows a division of human sera into three qualitatively different patterns characterized by the presence of a fast-moving group-specific component (Gc1–1), a slow-moving component (Gc2–2), which in immuno-electrophoresis both give normally arc-shaped precipitates, or the simultaneous presence of both fast- and slow-moving components (Gc2–1), which in immuno-electrophoresis give an extended two-peaked precipitate due to a reaction of immunological identity between these electrophoretically different although immunologically identical fast-and slow-moving components1. Investigations on sera from 42 families with 137 children and more than 600 mother–child combinations have shown that these serum patterns are genetically determined by two autosomal alleles (Gc1andGc2) without dominance where the serum typesGc1–1 andGc2–2 are the homozygotes andGc2–1 the heterozygote. Up to now, no exceptions to this genetical theory or unresolved typing difficulties has been found in the material investigated2,3.