Engineered cancer cell membranes: An emerging agent for efficient cancer theranostics.
Engineered cancer cell membranes: An emerging agent for efficient cancer theranostics.
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工程性癌细胞膜：一种新兴癌症疗法的新兴剂。
DOI：
10.1002/exp.20210171
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发表时间：
2022-02
期刊：
影响因子：
--
通讯作者：
Shen, Mingwu
中科院分区：
文献类型：
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作者：
Guo, Yunqi;Wang, Zhiqiang;Shi, Xiangyang;Shen, Mingwu
关键词：
对于有效的癌症治疗诊断，纳米材料的表面修饰在提高靶向能力和减少与正常组织的非特异性相互作用方面发挥着重要作用。近年来，以癌细胞膜（CCM）涂层为代表的仿生技术被认为是增强纳米材料生物相容性和靶向特异性的一种有前途的方法。此外，工程化CCM（ECCM）与CCM的天然生物学特性和其他细胞或蛋白质的特定功能相结合，为癌症治疗诊断领域提供了更多可能性。本文综述了ECCM设计和制备的最新进展，并综述了ECCM在靶向递送、免疫激活和循环肿瘤细胞检测等方面的应用。最后，简要讨论了ECCM发展的当前挑战和未来前景。工程化癌细胞膜 (ECCM) 包括混合 CCM 和功能化 CCM，为癌症治疗诊断领域提供了越来越多的可能性。本综述总结了 ECCM 在不同生物医学应用中的开发最新进展，特别是在靶向药物递送、免疫诱导以及循环肿瘤细胞捕获和检测方面。
For efficient cancer theranostics, surface modification of nanomaterials plays an important role in improving targeting ability and reducing the non‐specific interactions with normal tissues. Recently, the biomimetic technology represented by coating of cancer cell membranes (CCMs) has been regarded as a promising method to strengthen the biocompatibility and targeting specificity of nanomaterials. Furthermore, the engineered CCMs (ECCMs) integrated with the natural biological properties of CCMs and specific functions from other cells or proteins have offered more possibilities in the field of cancer theranostics. Herein, the recent progresses in the design and preparation of ECCMs are summarized, and the applications of ECCMs in targeting delivery, activation of immunity, and detection of circulating tumor cells are reviewed. Finally, the current challenges and future perspectives with regard to the development of ECCMs are briefly discussed. Engineered cancer cell membranes (ECCMs) including hybrid CCMs and functionalized CCMs have offered increasing possibilities in the field of cancer theranostics. This review summarizes the recent advances in the development of ECCMs for different biomedical applications, in particular for targeted drug delivery, immunity induction, and circulating tumor cell capture and detection.