Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of Gelsemium alkaloids for A431 epidermoid carcinoma cells
Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of Gelsemium alkaloids for A431 epidermoid carcinoma cells
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DOI：
10.1021/np060016o
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发表时间：
2006-04-01
影响因子：
5.1
通讯作者：
Takayama, H
中科院分区：
文献类型：
--
作者：
Kitajima, M;Nakamura, T;Takayama, H
从钩吻花叶中分离得到 4 种新的钩吻型吲哚生物碱 (1-4)，以及 11 种已知生物碱。通过光谱分析，结构分别确定为 14-乙酰氧基格尔色碱 (1)、14-乙酰氧基-15-羟基格尔色碱 (2)、14-羟基-19-氧代格尔色碱 (3) 和 14-乙酰氧基格尔色碱 (4)。使用 A431 人表皮样癌细胞系评估了 14 种钩吻生物碱（包括两种新化合物 (1, 2)）的细胞毒性作用。其中，明胶型生物碱 14-乙酰氧基明胶 (1)、14,15-二羟基明胶 (5)、明胶 (7) 和明胶 (8) 显示出有效的细胞毒性作用。
Four new gelsedine-type indole alkaloids (1-4) were isolated from the leaves of Gelsemium elegans, together with 11 known alkaloids. The structures were determined as 14-acetoxygelsenicine ( 1), 14-acetoxy-15-hydroxygelsenicine ( 2), 14-hydroxy-19-oxogelsenicine ( 3), and 14-acetoxygelselegine ( 4), respectively, by spectroscopic analysis. The cytotoxic effects of 14 Gelsemium alkaloids including two new compounds ( 1, 2) were evaluated using the A431 human epidermoid carcinoma cell line. Of these, the gelsedine-type alkaloids 14-acetoxygelsenicine ( 1), 14,15-dihydroxygelsenicine ( 5), gelsedine ( 7), and gelsemicine ( 8) showed potent cytotoxic effects.