The role of intestinal microbiota of the marine fish (Acanthopagrus latus) in mercury biotransformation
The role of intestinal microbiota of the marine fish (Acanthopagrus latus) in mercury biotransformation
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海鱼（Acanthopagrus latus）肠道微生物群在汞生物转化中的作用
DOI：
10.1016/j.envpol.2021.116768
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发表时间：
2021
影响因子：
8.9
通讯作者：
Wang Xun
中科院分区：
文献类型：
--
作者：
Yang Tao-Tao;Liu Yong;Tan Sha;Wang Wen-Xiong;Wang Xun
无机汞(IHG)和有机汞(MeHg)都可以通过甲基化或去甲基化相互转化，导致汞在鱼类中的形态和分布发生变化。然而，汞在鱼类体内的生物转化还不完全清楚，这一过程中的关键因素也不清楚。本文研究了汞在海鱼(Acanthopagus Latus)体内的转化规律，并探讨了肠道微生物区系在汞生物转化中的作用。我们首次证明了汞甲基化或去甲基化分别发生在饲料IHG或甲基汞暴露下的鱼类肠道中。观察到去甲基化的速度比甲基化快，这表明去甲基化可以显著影响鱼类中汞的形态。本研究还强烈表明，肠道微生物区系在汞的生物转化中起着主导作用，从而显著影响汞在鱼类体内的整体积累和分布。甲基化汞和去甲基汞处理分别提高了汞甲基化和去甲基化的丰度。此外，汞暴露还改变了肠道微生物区系组成。这项研究强调了肠道微生物群在鱼类体内汞生物转化中的重要性，并提出调节肠道微生物群可能是减少鱼类汞污染的一个可能的解决方案。
Both inorganic (IHg) and organic (MeHg) forms of Hg can be converted into each other by methylation or demethylation, leading to changes of Hg speciation and distribution in fish. However, Hg biotransformation in fish is not thoroughly understood and the key factors in this process are unclear. The present study investigated thein vivoHg transformation in a marine fish (Acanthopagrus latus) and explored the roles of intestinal microbiota in Hg biotransformation. We first demonstrated that Hg methylation or demethylation occurred in the fish gut under dietary IHg or MeHg exposure, respectively. The demethylation was observed to be faster than methylation, suggesting that demethylation could significantly influence the Hg speciation in fish. This study also strongly suggested that intestinal microbiota played a predominant role in Hg biotransformation and thus significantly affected the overall Hg accumulation and distribution in fish body. The richness of Hg methylators or demethylators was elevated under IHg or MeHg treatment, respectively. Furthermore, the intestinal microbiota composition was also altered by Hg exposure. This study highlights the importance of intestinal microbiota in Hg biotransformation in fish body, and suggests that modulating the gut microbiome could be a possible solution to minimize Hg contamination in fish.