High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia
High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia
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DOI：
10.5603/gp.2016.0021
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发表时间：
2016-01-01
影响因子：
1.3
通讯作者：
Taner, Cuneyt Eftal
中科院分区：
文献类型：
--
作者：
Gezer, Cenk;Ekin, Atalay;Taner, Cuneyt Eftal
目的：我们的研究的目的是确定是否第一孕期嗜中性粒细胞淋巴细胞比率（NLR）和板让淋巴细胞比率（PLR）将是有用的，作为新的预测随后先兆子痫。材料和方法：从三级转诊中心的先兆子痫和健康对照妇女的病历进行了回顾性评价。比较两组患者的临床特征及孕早期血红蛋白、白细胞、中性粒细胞、淋巴细胞、血小板、NLR和PLR水平。进行受试者工作特征曲线（ROC）分析以确定预测先兆子痫的最佳NLR和PLR水平。中性粒（p < 0.001），血小板（p < 0.001），NLR（p < 0.001）和PLR（p < 0.001）水平显著升高，而与对照组相比，先兆子痫组的血红蛋白浓度（p = 0.003）显著较低。在多变量回归分析中，NLR（OR 1.43; 95% CI 1.21-1.76; p = 0.005）和PLR（OR 1.38; 95% CI 1.15-1.63; p = 0.008）是最有力的预测变量。NLR和PLR的ROC下面积分别为0.716和0.705。NLR = 3.08和PLR = 126.8的临界值预测先兆子痫的敏感性分别为74.6%和71.8%，特异性分别为70.1%和72.4%.Conclusions：高NLR和PLR在孕早期是随后先兆子痫的独立预测因子。
Objectives: The aim of our study is to determine whether first-trimester neutrophil-to-lymphocyte ratio (NLR) and plate-let-to-lymphocyte ratio (PLR) would be useful as new predictors of subsequent preeclampsia.Material and methods: Medical records of women with preeclampsia and healthy controls from a tertiary referral center were retrospectively evaluated. The two groups were compared in terms of clinical characteristics and first-trimester levels of hemoglobin, leukocyte, neutrophil, lymphocyte, platelet, NLR and PLR. Receiver operating characteristic curve (ROC) analysis was performed to identify the optimal NLR and PLR levels predicting preeclampsia.Results: Neutrophil (p < 0.001), platelet (p < 0.001), NLR (p < 0.001) and PLR (p < 0.001) levels were significantly elevated, whereas hemoglobin concentration (p = 0.003) was significantly lower in the group with preeclampsia as compared to the control group. On multivariate regression analysis, NLR (OR 1.43; 95% CI 1.21-1.76; p = 0.005) and PLR (OR 1.38; 95% CI 1.15-1.63; p = 0.008) were the most powerful predictive variables. The area under the ROC was 0.716 and 0.705 for NLR and PLR, respectively. The cut-off values of NLR = 3.08 and PLR = 126.8 predicted preeclampsia with the sensitivity of 74.6% and 71.8% and specificity of 70.1% and 72.4%, respectively.Conclusions: High NLR and PLR during the first trimester are independent predictors of subsequent preeclampsia.