Dynamic mechanisms of blood vessel growth
Dynamic mechanisms of blood vessel growth
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DOI：
10.1088/0951-7715/19/1/000
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发表时间：
2006-01-01
期刊：
影响因子：
1.7
通讯作者：
Glazier, JA
中科院分区：
文献类型：
--
作者：
Merks, RMH;Glazier, JA
从最初分散的细胞形成多边形结构的原始血管是脊椎动物循环系统发育的第一步。这个最初的血管网络后来扩展形成新的血管，主要是通过萌芽机制。我们回顾了一系列最近的结果与蒙特卡洛模型的chemotactically迁移细胞，可以解释从头血管生长和血管发芽方面。我们建议，初始网络的形式，通过一个类似的不稳定性依赖于细胞的形状，或通过一个替代的接触抑制运动机制，也再现方面的萌芽血管生长。
The formation of a polygonal configuration of proto-blood-vessels from initially dispersed cells is the first step in the development of the circulatory system in vertebrates. This initial vascular network later expands to form new blood vessels, primarily via a sprouting mechanism. We review a range of recent results obtained with a Monte Carlo model of chemotactically migrating cells which can explain both de novo blood vessel growth and aspects of blood vessel sprouting. We propose that the initial network forms via a percolation-like instability depending on cell shape, or through an alternative contact-inhibition of motility mechanism which also reproduces aspects of sprouting blood vessel growth.