Adult neurogenesis in the central olfactory pathway in the absence of receptor neuron turnover in Libinia emarginata.
Adult neurogenesis in the central olfactory pathway in the absence of receptor neuron turnover in Libinia emarginata.
复制标题
在 Libinia emarginata 缺乏受体神经元更新的情况下，中枢嗅觉通路中的成体神经发生。
DOI：
10.1111/j.1460-9568.2005.04449.x
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Beltz,BarbaraS
中科院分区：
文献类型：
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作者：
Sullivan,JeremyM;Beltz,BarbaraS
终身神经发生是一系列遗传多样性动物嗅觉通路的特征。在脊椎动物和无脊椎动物中，大脑中嗅觉中间神经元的终身增加与嗅觉器官中嗅觉受体神经元的持续增殖平行发生。有人提出，这两个过程在功能上是相关的，新的嗅觉中间神经元被添加到适应新的嗅觉受体神经元添加在外围。虽然这还没有被直接测试，因为这两个过程是不容易分开的，这个问题可以在螃蟹的嗅觉通路中解决，Libinia embryoata。不像大多数十足类甲壳动物，蜕皮和生长整个生命，L。Emperatata有一个终端，成熟换羽后，动物成为anecdysic（停止换羽）。由于甲壳类动物中新的受体神经元的增加与蜕皮有关，因此比较未成熟和成熟的神经发生。embryataprovides一个机会，以检查在嗅觉通路的中枢和外周神经发生的相互依赖性。本研究表明，L.在终末换羽时，嗅觉中间神经元的增殖和分化在成熟动物中继续。因此，与一般的假设相反，这种物种的中央嗅觉通路中的连续神经发生并不作为涉及中央和外周神经发生的共同调节的过程的一部分而发生。这些发现表明，外周神经发生是不是一个连续的神经发生在中央嗅觉通路的要求。
Life‐long neurogenesis is a characteristic feature of the olfactory pathways of a phylogenetically diverse array of animals. In both vertebrates and invertebrates, the life‐long addition of olfactory interneurons in the brain occurs in parallel with the continuous proliferation of olfactory receptor neurons in the olfactory organ. It has been proposed that these two processes are related functionally, with new olfactory interneurons being added to accommodate the new olfactory receptor neurons added in the periphery. While this has not been tested directly because the two processes are not readily separable, this question can be addressed in the olfactory pathway of the crab,Libinia emarginata. Unlike most decapod crustaceans, which moult and grow throughout life,L. emarginatahas a terminal, maturational moult after which animals become anecdysic (stop moulting). Because the addition of new receptor neurons in crustaceans is associated with moulting, a comparison of neurogenesis in immature and matureL. emarginataprovides an opportunity to examine the interdependence of central and peripheral neurogenesis in the olfactory pathway. This study demonstrates that the continuous addition of olfactory receptor neurons inL. emarginataceases at the terminal moult but that proliferation and differentiation of olfactory interneurons in the brain continues in mature animals. Contrary to the general assumption, therefore, continuous neurogenesis in the central olfactory pathway of this species does not occur as part of a process involving the coregulation of central and peripheral neurogenesis. These findings suggest that peripheral neurogenesis is not a requirement for continuous neurogenesis in the central olfactory pathway.