Effectiveness of Echinochrome on HFD-Induced Hyperlipidemia in Rats
Effectiveness of Echinochrome on HFD-Induced Hyperlipidemia in Rats
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DOI：
10.1007/s13659-019-00221-4
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发表时间：
2019-10-18
影响因子：
4.7
通讯作者：
Hassanein, Sarah S.
中科院分区：
文献类型：
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作者：
Fahmy, Sohair R.;Zaki, Nashwah Ismail;Hassanein, Sarah S.
肥胖已被确定为包括身体不同器官框架的疾病进展的扩大危险。在本研究中，我们评估了棘色素（Ech）色素在高脂饮食（HFD）诱导的高脂血症大鼠中的降血脂特性。建立大鼠高脂血症模型后，随机分为正常对照组、高脂饮食组、阿托伐他汀（ATOR）组（80 mg/kg）、艾司他汀（Ech）组（1 mg/kg）和ATOR + Ech联合组。结果表明，Ech改善肥胖大鼠的血脂，肝功能，肾功能和抗氧化指标。本研究结果表明Ech对肥胖大鼠具有降血脂作用。
Obesity has been identified with an expanded danger of a progression of illnesses that include different organ-frameworks of the body. In the present examination, we evaluated the hypolipidemic properties of Echinochrome (Ech) pigment in a high-fat diet (HFD) induced hyperlipidemia in rats. After the hyperlipidemic model was set up, rats were haphazardly separated into five groups as follows: normal control group, HFD group, Atorvastatin (ATOR) group (80 mg/kg), Ech group (1 mg/kg) and combined group ATOR + Ech. The outcomes demonstrated that Ech improves lipid profile, liver functions, kidney functions and antioxidant markers of obese rats. The findings of the present investigation indicated that the Ech possesses hypolipidemic potential in obese rats.