MATRICS cognitive consensus battery (MCCB) performance in children, adolescents, and young adults
MATRICS cognitive consensus battery (MCCB) performance in children, adolescents, and young adults
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DOI：
10.1016/j.schres.2013.11.023
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发表时间：
2014-01-01
影响因子：
4.5
通讯作者：
Malhotra, Anil K.
中科院分区：
文献类型：
--
作者：
Nitzburg, George C.;DeRosse, Pamela;Malhotra, Anil K.
背景资料：精神分裂症的神经发育模型表明，认知缺陷可能在儿童和青少年时期观察到，早在精神病症状发作之前。因此，阐明儿童期和青春期正常认知发展的轨迹可能为识别与精神分裂症发展相关的特定异常提供基础。MATRICS共识认知成套测验（MCCB）旨在用于针对精神分裂症中最常见的认知缺陷的临床试验，可能提供一种理解这种轨迹的机制。然而，迄今为止，尚无MCCB在健康儿童和青少年中的性能数据。本研究旨在建立MCCB在健康儿童，青少年和年轻adults.Methods的性能数据：MCCB管理的190名健康受试者之间的年龄为8和23岁的社区样本。所有MCCB域的分数转换为T-分数使用样本的平均值和标准差和性别和年龄strature.Results之间的显着性能差异进行了比较：分析显示年龄效应二次趋势在所有MCCB域，这是一致的研究表明，接近青春期后期的儿童认知能力的改善趋于平稳。控制年龄后的性别效应只提出了一个MCCB域，与男性表现出众所周知的空间推理的优势。结论：利用此性能数据可能有助于未来的研究，寻求阐明具体的赤字，可以预测以后的发展SZ。(C)2013爱思唯尔有限公司版权所有。
Background: Neurodevelopmental models of schizophrenia suggest that cognitive deficits may be observed during childhood and adolescence, long before the onset of psychotic symptoms. Elucidating the trajectory of normal cognitive development during childhood and adolescence may therefore provide a basis for identifying specific abnormalities related to the development of schizophrenia. The MATRICS Consensus Cognitive Battery (MCCB), which was designed for use in clinical trials targeting cognitive deficits most common in schizophrenia, may provide a mechanism to understand this trajectory. To date, however, there is no performance data for the MCCB in healthy children and adolescents. The present study sought to establish performance data for the MCCB in healthy children, adolescents, and young adults.Methods: The MCCB was administered to a community sample of 190 healthy subjects between the ages of 8 and 23 years. All MCCB domain scores were converted to T-scores using sample means and standard deviations and were compared for significant performance differences between sex and age strata.Results: Analyses revealed age effects following quadratic trends in all MCCB domains, which is consistent with research showing a leveling off of childhood cognitive improvement upon approaching late adolescence. Sex effects after controlling for age only presented for one MCCB domain, with males exhibiting well-known spatial reasoning advantages.Conclusions: Utilizing this performance data may aid future research seeking to elucidate specific deficits that may be predictive of later development of SZ. (C) 2013 Elsevier B.V. All rights reserved.