Hyperpolarization of deuterated metabolites via remote cross-polarization and dissolution dynamic nuclear polarization.
Hyperpolarization of deuterated metabolites via remote cross-polarization and dissolution dynamic nuclear polarization.
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通过远程交叉极化和溶解动态核极化实现氘化代谢物的超极化。
DOI：
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发表时间：
2014
影响因子：
3.3
通讯作者：
G. Bodenhausen
中科院分区：
文献类型：
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作者：
Basile Vuichoud;Jonas Milani;A. Bornet;R. Melzi;S. Jannin;G. Bodenhausen
在氘代分子中，如[1-（13）C]-d3，低温（1.2K）下的Hartmann-Hahn交叉极化（CP）与溶解动态核极化（D-DNP）相结合可以增强（13）C核的自旋极化。极化从远程溶剂质子转移到感兴趣的（13）C自旋。这不仅允许略微减少建立时间，而且允许增加极化水平，并在从极化器转移到NMR或MRI系统期间和之后延长增强的（13）C极化的寿命T1（（13）C）。这扩展了可以监测代谢过程和化学反应的时间尺度。
In deuterated molecules such as [1-(13)C]pyruvate-d3, the nuclear spin polarization of (13)C nuclei can be enhanced by combining Hartmann-Hahn cross-polarization (CP) at low temperatures (1.2 K) with dissolution dynamic nuclear polarization (D-DNP). The polarization is transferred from remote solvent protons to the (13)C spins of interest. This allows one not only to slightly reduce build-up times but also to increase polarization levels and extend the lifetimes T1((13)C) of the enhanced (13)C polarization during and after transfer from the polarizer to the NMR or MRI system. This extends time scales over which metabolic processes and chemical reactions can be monitored.