VASCULAR ENDOTHELIUM AS THE VULNERABLE ELEMENT IN TUMORS
VASCULAR ENDOTHELIUM AS THE VULNERABLE ELEMENT IN TUMORS
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DOI：
10.3109/02841868409136015
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
DENEKAMP, J
中科院分区：
文献类型：
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作者：
DENEKAMP, J
肿瘤和正常组织中的血管之间的差异已经被认识了很长一段时间，但很少有人在[人类]癌症治疗中利用这一点。概述了血管介导的损伤与几种现有的治疗形式的可能贡献。介入放射学和某种程度上的热疗最明显地通过缺血性细胞死亡介导。许多肿瘤的成功治愈与放射治疗，并与全身化疗看到的完全消退也可能部分是由于血管成分的损害。本文综述了正常血管和肿瘤血管内皮细胞的增殖特点。这些来自单次注射或重复给予氚化胸苷。周转时间之间存在着非常大的和一贯的差异。肿瘤内皮细胞的增殖速度比成人任何正常组织内皮细胞快20-2000倍。唯一的例外是胎盘，它比肿瘤内皮细胞增殖得更快。增殖率的巨大差异，加上壁结构差，缺乏神经支配和缺乏侧支供应，使血管成为肿瘤治疗的有吸引力的靶点。概述了利用这一点的可能手段。
The difference between blood vessels in tumors and normal tissues has been recognized for a long time, but little has been done to exploit this in [human] cancer therapy. An overview is presented of the possible contribution of vascular mediated injury with several existing forms of treatment. Interventive radiology and, to some extent, hyperthermia are most obviously mediated through ischemic cell death. The successful cure of many tumors with radiation, and the complete regressions seen with systemic chemotherapy may also be partially due to a vascular component of damage. The proliferation characteristics of endothelial cells in normal and tumor blood vessels are summarized. These were derived from single injections or repeated administration of tritiated thymidine. A very large and consistent difference exists between the turnover times. The tumor endothelium is proliferating 20-2000 times faster than any normal tissue endothelium in the adult. The single exception is the placenta which has even more rapid proliferation than the tumor endothelium. The large difference in proliferation rates, coupled with the poor wall structure, lack of innervation and lack of collateral supply, make the blood vessels an attractive target for tumor therapy. Possible means of utilizing this are outlined.