In vitro screening of two Nigerian medicinal plants (Vernonia amygdalina and Annona senegalensis) for anthelmintic activity
In vitro screening of two Nigerian medicinal plants (Vernonia amygdalina and Annona senegalensis) for anthelmintic activity
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DOI：
10.1016/s0304-4017(03)00040-2
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发表时间：
2003-04-02
影响因子：
2.6
通讯作者：
Bowman, DD
中科院分区：
文献类型：
--
作者：
Alawa, CBI;Adamu, AM;Bowman, DD
在尼日利亚，当地/小农畜牧业农民使用的两种植物Veronia amygdalina和Annona senegalensis作为驱虫剂，使用捻转血矛线虫卵筛选体外驱虫活性。苦杏仁提取物在浓度高达11.2 mg/ml时未显示任何显著活性。A.在7.1 mg/ml的浓度下，塞内加尔对虾的卵孵化率显著降低（P < 0.001）。用粪培养法对A.当使用整个磨碎的植物材料时，随着浓度从1%增加到10%（粪便培养物中的（w/w）），塞内加尔线虫显示出幼虫回收率的显著降低（P < 0.001）。尽管传统兽医和当地畜牧业者声称这两种植物都是有效的驱虫药，我们的研究结果表明，只有A。Senegalensis显示出有希望的驱虫活性，特别是在一些农民使用磨碎的全植物材料的情况下。(C)2003 Elsevier Science B. V.保留所有权利。
Veronia amygdalina and Annona senegalensis, two plants used by local/smallholder livestock farmers in Nigeria as anthelmintic were screened for in vitro anthelmintic activity using Haemonchus contortus eggs. The extract of V. amygdalina did not show any significant activity at concentrations up to 11.2 mg/ml. The extract of A. senegalensis showed significant (P < 0.001) reduction in egg hatch at a concentration of 7.1 mg/ml. The in vitro fecal culture of eggs with A. senegalensis showed significant (P < 0.001) reductions in larval recovery with increasing concentrations from 1 to 10% ((w/w) in fecal culture) when whole ground plant material was used. Although traditional veterinary healers and local livestock farmers claim both plants are effective as anthelmintics, our result indicate that only A. senegalensis showed promising anthelmintic activity especially with use of ground whole plant materials as used by some farmers. (C) 2003 Elsevier Science B.V. All rights reserved.