Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis
Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis
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第一个人类逆转录病毒HTLV-1的发现、其独特的调控机制以及对发病机制的见解
作者：
Mitsuaki Yoshida
我简要回顾了第一个人类逆转录病毒，人类T细胞白血病病毒1型的发现和表征，重点是日本研究人员的贡献。本文还对Tax和雷克斯独特的病毒调节机制、ATL的病因学和Tax可能的致白血病机制进行了简要讨论。
I briefly review the discovery and characterization of the first human retrovirus, human T-cell leukemia virus type 1, focusing on contributions from Japanese researchers. The unique regulatory mechanisms for the viral regulation with Tax and Rex, etiology of ATL and possible leukemogenic mechanism with Tax are also discussed briefly.