Gangliosides in DNA virus-transformed and spontaneously transformed tumorigenic mouse cell lines.
Gangliosides in DNA virus-transformed and spontaneously transformed tumorigenic mouse cell lines.
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DNA病毒转化和自发转化的致瘤小鼠细胞系中的神经节苷脂。
DOI：
10.1073/pnas.63.4.1290
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发表时间：
1969
影响因子：
11.1
通讯作者：
V. McFarland
中科院分区：
文献类型：
--
作者：
P. Mora;R. Brady;R. Bradley;V. McFarland
在SV40病毒转化的小鼠细胞系中，观察到较高神经节苷脂同系物二唾液酸神经酰胺四己糖苷和单唾液酸神经酰胺四己糖苷减少。这种变化仅在携带病毒基因组的细胞中观察到，并且它与组织培养中饱和密度的增加和免疫活性同源宿主中的排斥反应相关。这表明这种变化是病毒调节的功能之一，并推测它与病毒转化细胞的排斥有关。
In mouse cell lines transformed by SV40 virus, a decrease was observed in the higher ganglioside homologues disialo-ceramidetetrahexoside and monosialo-ceramidetetrahexoside. Such change was observed only in cells which carry the virus genome, and it correlated with increased saturation density in tissue culture and with rejection in immunologically competent syngeneic host. This indicates that the change is one of the virus-regulated functions, and it is postulated that it relates to the rejection of the virus-transformed cells.