Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.
Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.
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DOI：
10.1016/j.tins.2017.01.001
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发表时间：
2017-03
影响因子：
15.9
通讯作者：
Wollmuth LP
中科院分区：
文献类型：
--
作者：
Zhou HX;Wollmuth LP
NMDA 受体 (NMDAR) 是由兴奋性神经递质谷氨酸激活的离子通道，对大脑功能的各个方面（包括学习和记忆形成）至关重要。分布在 NMDAR 亚基中的错义突变与一系列神经系统疾病有关。最近的结构、功能和计算研究对谷氨酸结合与离子通道开放之间的激活过程产生了许多见解，这对于 NMDAR 生理学和病理生理学至关重要。该领域似乎即将取得突破，包括解决激活过程中基本步骤的构象和能量学以及错义突变对受体功能影响的原子级建模的令人兴奋的前景。未来最有前途的策略是通过多种方法的强有力整合。
NMDA receptors (NMDARs) are ion channels activated by the excitatory neurotransmitter glutamate and essential to all aspects of brain function, including learning and memory formation. Missense mutations distributed throughout NMDAR subunits have been associated with an array of neurological disorders. Recent structural, functional, and computational studies have generated many insights into the activation process connecting glutamate binding to ion channel opening, which is central to NMDAR physiology and pathophysiology. The field appears poised for breakthroughs, including the exciting prospect of resolving the conformations and energetics of elementary steps along the activation process and atomic-level modeling for the effects of missense mutations on receptor function. The most promising strategy going forward is through strong integration of multiple approaches.