ORAL VERSUS INTRAMUSCULAR VITAMIN SUPPLEMENTATION FOR HYPOVITAMINOSIS IN THE ELDERLY
ORAL VERSUS INTRAMUSCULAR VITAMIN SUPPLEMENTATION FOR HYPOVITAMINOSIS IN THE ELDERLY
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DOI：
10.1111/j.1532-5415.1980.tb00123.x
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发表时间：
1980-01-01
影响因子：
6.3
通讯作者：
JASLOW, SP
中科院分区：
文献类型：
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作者：
BAKER, H;FRANK, O;JASLOW, SP
对疗养院 228 名流动老年居民的血液中的硫胺素、叶酸、生物素、核黄素、烟酸盐、泛酸盐、胡萝卜素以及维生素 B6、B12、A、E 和 C 进行了测量。他们的平均年龄为 87 岁（范围为 6-102 岁）。没有人接受过重大外科手术：他们的饮食良好，并且每人每天至少服用 1 粒复合维生素药丸，持续 3-5 个月。在学习之前。对 204 名 20-50 岁健康志愿者组成的对照组进行了研究。在 228 名老年受试者中，尽管口服维生素补充剂，仍有 88 名 (39%) 表现出维生素缺乏。发现维生素 B6、烟酸、维生素 B12、叶酸和硫胺素单一或多重缺乏。 3 个月后，一次即刻后。注射多种维生素（不补充其他维生素）后，89-100% 缺乏维生素的老年人的血液中不再检测到这些缺陷。我是。对于老年人来说，维持足够的维生素血液水平比口服维生素补充更有效的方法是：i.m.该途径显然促进了组织储存足够维生素的饱和度，以满足需要，并消除了可能由于药物干扰或小肠萎缩而导致的维生素吸收不良问题。
Thiamine, folate, biotin, riboflavine, nicotinates, pantothenate, carotenes and vitamins B6, B12, A, E and C were measured in the blood of 228 elderly ambulatory residents of a nursing home. Their mean age was 87 yr (range, 6-102). None had undergone major surgical procedures: their diet was good and each had received at least 1 multivitamin pill every day for 3-5 mo. before the study. A comparison group of 204 healthy volunteers aged 20-50 was studied. Of the 228 elderly subjects 88 (39%) showed vitamin deficits despite oral vitamin supplementation. Single and multiple deficits of vitamin B6, nicotinate, vitaminB12, folate and thiamine were found. At 3 mo., after a single i.m. injection of multivitamins (with no other vitamin supplementation) these deficits were no longer detectable in the blood of 89-100% of the vitamin-deficient elderly. I.m. rather than oral vitamin supplementation is a more effective method for maintaining adequate blood levels of vitamins in the elderly: the i.m. route apparently promotes saturation of tissue stores with enough vitamins to meet the needs and obviates problems of vitamin malabsorption possibly due to drug interference or small-bowel atrophy.