Opposing roles for dopamine and serotonin in the modulation of human spatial working memory functions
Opposing roles for dopamine and serotonin in the modulation of human spatial working memory functions
复制标题
DOI：
10.1093/cercor/8.3.218
复制
发表时间：
1998-04-01
期刊：
影响因子：
3.7
通讯作者：
Depue, RA
中科院分区：
文献类型：
--
作者：
Luciana, M;Collins, PF;Depue, RA
神经认知研究主要关注单胺能对广泛行为模式的影响。例如，多巴胺（DA）通常促进边缘和皮质网络内的信息传递，以促进寻求奖励的行为。具体来说，前额皮质中的 DA 活动调节非人类灵长类动物和人类执行空间工作记忆任务的能力。血清素 (5HT) 限制 DA 的活性，导致 DA 和 5HT 在情绪和运动行为方面呈相反关系。 5HT 在限制人类前额引导的空间工作记忆 (WM) 过程中的作用尚未得到实证证明，但如果这些神经递质活动原理在皮质网络中成立，那么它是一个合乎逻辑的研究途径。在这项研究中，正常人在双盲、重复测量、安慰剂对照设计中，使用（i）溴隐亭（一种 DA 激动剂）和（ii）芬氟拉明（一种血清素激动剂）在药物挑战下完成了视觉空间 WM 任务。研究结果表明，溴隐亭促进了空间延迟记忆表现，但不是即时记忆表现。芬氟拉明导致空间记忆延迟受损。这些影响不是由于非特异性唤醒、注意力、感觉运动或知觉变化造成的。这些发现表明，单胺能神经递质（DA 和 5HT）可能在皮质网络内相互作用，调节特定认知行为的表达，特别是与目标导向活动相关的努力过程。
Neurocognitive research has focused on monoaminergic influences over broad behavior patterns. For example, dopamine (DA) generally facilitates informational transfer within limbic and cortical networks to promote reward-seeking behavior. Specifically, DA activity in prefrontal cortex modulates the ability for nonhuman primates and humans to perform spatial working memory tasks. Serotonin (5HT) constrains the activity of DA, resulting in an opposing relationship between DA and 5HT with respect to emotional and motor behaviors. A role for 5HT in constraining prefrontally guided spatial working memory (WM) processes in humans has not been empirically demonstrated but is a logical avenue for study if these principles of neurotransmitter activity hold within cortical networks. In this study, normal humans completed a visuospatial WM task under pharmacological challenge with (i) bromocriptine, a DA agonist and (ii) fenfluramine, a serotonin agonist, in a double-blind, repeated-measures, placebo-controlled design. Findings indicate that bromocriptine facilitated spatial delayed, but not immediate, memory performance. Fenfluramine resulted in impaired delayed spatial memory. These effects were not due to nonspecific arousal, attentional, sensorimotor or perceptual changes. These findings suggest that monoaminergic neurotransmitters (DA and 5HT) may interact within cortical networks to modulate the expression of specific cognitive behaviors, particularly effortful processes associated with goal-directed activity.