Snail Family Regulation and Epithelial Mesenchymal Transitions in Breast Cancer Progression
Snail Family Regulation and Epithelial Mesenchymal Transitions in Breast Cancer Progression
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DOI：
10.1007/s10911-010-9179-8
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发表时间：
2010-06-01
影响因子：
2.5
通讯作者：
Savagner, Pierre
中科院分区：
文献类型：
--
作者：
Garcia de Herreros, Antonio;Peiro, Sandra;Savagner, Pierre
自最初的描述以来，上皮细胞和间质细胞之间的相互转化（分别设计为上皮-间质或间质-上皮转变，EMT或MET）受到了特别关注，因为它为上皮细胞提供了迁移特征。使用细胞系的不同研究已经确定了能够调节这一过程的细胞因子、细胞间信号元件和转录因子。特别是，Snail 家族成员作为 EMT 关键效应器的识别，为研究这一细胞过程开辟了新途径。在本文中，我们讨论了控制 EMT 的分子途径，显示出非常严格且相互依赖的调节。我们还使用乳腺作为细胞模型分析了 EMT 和 Snail 基因在肿瘤发生过程中的贡献。
Since its initial description, the interconversion between epithelial and mesenchymal cells (designed as epithelial-mesenchymal or mesenchymal-epithelial transition, EMT or MET, respectively) has received special attention since it provides epithelial cells with migratory features. Different studies using cell lines have identified cytokines, intercellular signaling elements and transcriptional factors capable of regulating this process. Particularly, the identification of Snail family members as key effectors of EMT has opened new ways for the study of this cellular process. In this article we discuss the molecular pathways that control EMT, showing a very tight and interdependent regulation. We also analyze the contribution of EMT and Snail genes in the process of tumorigenesis using the mammary gland as cellular model.