Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma.
Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma.
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DOI：
10.1186/1477-044x-2-3
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发表时间：
2004-03-25
期刊：
影响因子：
--
通讯作者：
Kobayashi T
中科院分区：
文献类型：
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作者：
Matsuoka F;Shinkai M;Honda H;Kubo T;Sugita T;Kobayashi T
我们已经开发了磁铁矿阳离子脂质体（MCLs），并将其应用于局部热疗作为介体。MCL具有正电荷，并且在交变磁场（AMF）下通过磁滞损耗产生热量。在这项研究中，在仓鼠骨肉瘤的体内研究中检查了使用MCL的热疗的效果。将MCL注射到骨肉瘤中，然后进行AMF。肿瘤被加热到超过42°C，但其他正常组织没有被加热那么多。在100%的给药组仓鼠中观察到完全消退，而在对照组仓鼠中未观察到消退。在第12天，治疗仓鼠的平均肿瘤体积约为对照仓鼠的1/1000。在治疗的仓鼠中，在完全消退后3个月内未观察到骨肉瘤再生长。这些结果表明，这种治疗是有效的骨肉瘤。
We have developed magnetite cationic liposomes (MCLs) and applied them to local hyperthermia as a mediator. MCLs have a positive charge and generate heat under an alternating magnetic field (AMF) by hysteresis loss. In this study, the effect of hyperthermia using MCLs was examined in an in vivo study of hamster osteosarcoma. MCLs were injected into the osteosarcoma and then subjected to an AMF. The tumor was heated at over 42°C, but other normal tissues were not heated as much. Complete regression was observed in 100% of the treated group hamsters, whereas no regression was observed in the control group hamsters. At day 12, the average tumor volume of the treated hamsters was about 1/1000 of that of the control hamsters. In the treated hamsters, no regrowth of osteosarcomas was observed over a period of 3 months after the complete regression. These results suggest that this treatment is effective for osteosarcoma.