Education and heart failure: New insights from the atherosclerosis risk in communities study and mendelian randomization study
Education and heart failure: New insights from the atherosclerosis risk in communities study and mendelian randomization study
复制标题
教育与心力衰竭：社区研究和孟德尔随机研究中动脉粥样硬化风险的新见解
DOI：
10.1016/j.ijcard.2020.09.068
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发表时间：
2021-01-12
影响因子：
3.5
通讯作者：
Li, Wei-dong
中科院分区：
文献类型：
--
作者：
Liao, Li-zhen;Zhuang, Xiao-dong;Li, Wei-dong
Introduction: We aim to characterize the nature and magnitude of the prospective association between education and incident heart failure (HF) in the Atherosclerosis Risk in Communities (ARIC) Study and investigate any causal relevance to the association between them.Methods: The final sample size was 12,315 in this study. Baseline characteristics between education levels were compared using 1-way ANOVA test, the Kruskal-Wallis test, or the chi 2 test. We used the Kaplan-Meier estimate to compute the cumulative incident of HF by education levels and the difference in estimate was compared using the log-rank test. Cox hazard regression models were used to explore the association between education levels and incident HF. Two-sample Mendelian randomization (MR) based on publicly available summary-level data from genome-wide association studies (GWASs) was used to estimate the causal influence of the education and incident HF.Results: During a median follow-up of 25.1 years, 2453 cases (19.9%) of incident HF occurred. After multiple adjustments in the final model, participants in the intermediate and advanced education levels were still associated with 18% and 21% decreased rate of incident HF separately. In MR analysis, we detected a protective causal association between education and HF (P = 0.005).Conclusions: Participants with higher education levels were associated with a decreased rate of incident HF. There was a causal association between education and HF. (C) 2020 Elsevier B.V. All rights reserved.
