Synaptic Mechanisms for Bandwidth Tuning in Awake Mouse Primary Auditory Cortex
Synaptic Mechanisms for Bandwidth Tuning in Awake Mouse Primary Auditory Cortex
复制标题
清醒小鼠初级听觉皮层带宽调节的突触机制
DOI：
10.1093/cercor/bhy165
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Li I. Zhang
中科院分区：
文献类型：
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作者：
Haifu Li;Feixue Liang;Wen Zhong;Linqing Yan;Lucas Mesik;Zhongju Xiao;Huizhong W. Tao;Li I. Zhang
视觉皮层的空间尺寸调节被认为是感觉知觉的重要神经功能特性。然而，听觉系统中的类似机制仍然存在争议。在本研究中，细胞贴附记录在初级听觉皮层（A1）清醒的小鼠显示，兴奋性神经元可以分为三种类型，根据其带宽调谐配置文件响应于带通噪声（BPN）刺激：非单调（NM），平坦，单调，与后两个被认为是非调谐的带宽。带宽调谐的流行（即，NM）神经元从第4层到第2/3层显著增加。从相同的神经元连续的细胞贴附和全细胞电压钳记录，我们发现，兴奋性神经元的带宽偏好在很大程度上是由兴奋性突触输入，他们收到的，和带宽的选择性进一步增强平坦调谐抑制中观察到的所有细胞。后者可以归因于至少部分的小清蛋白抑制神经元的平坦调谐。听皮层神经元对BPN带宽的调节可能有助于复杂声音的加工。
Spatial size tuning in the visual cortex has been considered as an important neuronal functional property for sensory perception. However, an analogous mechanism in the auditory system has remained controversial. In the present study, cell-attached recordings in the primary auditory cortex (A1) of awake mice revealed that excitatory neurons can be categorized into three types according to their bandwidth tuning profiles in response to band-passed noise (BPN) stimuli: nonmonotonic (NM), flat, and monotonic, with the latter two considered as non-tuned for bandwidth. The prevalence of bandwidth-tuned (i.e., NM) neurons increases significantly from layer 4 to layer 2/3. With sequential cell-attached and whole-cell voltage-clamp recordings from the same neurons, we found that the bandwidth preference of excitatory neurons is largely determined by the excitatory synaptic input they receive, and that the bandwidth selectivity is further enhanced by flatly tuned inhibition observed in all cells. The latter can be attributed at least partially to the flat tuning of parvalbumin inhibitory neurons. The tuning of auditory cortical neurons for bandwidth of BPN may contribute to the processing of complex sounds.