On-Demand Removal of Bacterial Biofilms via Shape Memory Activation.
On-Demand Removal of Bacterial Biofilms via Shape Memory Activation.
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通过形状记忆激活对细菌生物膜的按需去除。
DOI：
10.1021/acsami.6b06900
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发表时间：
2016-08-24
影响因子：
9.5
通讯作者：
Ren D
中科院分区：
文献类型：
--
作者：
Gu H;Lee SW;Buffington SL;Henderson JH;Ren D
细菌生物膜是慢性感染和生物污垢的主要原因；然而，有效清除已建立的生物膜仍然具有挑战性。在这里，我们报告了一种新的策略，使用具有特定表面形貌的生物相容形状记忆聚合物来控制生物膜。这些表面既可以防止细菌附着，又可以在适度升高温度的情况下快速形状变化时去除已建立的生物膜，从而提供更持久的防污性能。我们证明，与静态平板对照相比，该策略可以实现铜绿假单胞菌生物被膜的总减少99.9%。对金黄色葡萄球菌和致尿路病原性大肠埃希氏菌的生物被膜也有抑制作用。
Bacterial biofilms are a major cause of chronic infections and biofouling; however, effective removal of established biofilms remains challenging. Here we report a new strategy for biofilm control using biocompatible shape memory polymers with defined surface topography. These surfaces can both prevent bacterial adhesion and remove established biofilms upon rapid shape change with moderate increase of temperature, thereby offering more prolonged antifouling properties. We demonstrate that this strategy can achieve a total reduction of Pseudomonas aeruginosa biofilms by 99.9% compared to the static flat control. It was also found effective against biofilms of Staphylococcus aureus and an uropathogenic strain of Escherichia coli.