Carbamazepine-Induced Hypersensitivity Syndrome Occurring in a Photodistributed Pattern

Carbamazepine-Induced Hypersensitivity Syndrome Occurring in a Photodistributed Pattern
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卡马西平诱发的光分布过敏综合征

DOI:
10.1159/000093861
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发表时间:
2006
期刊:
影响因子:
3.4
通讯作者:
S. Ibbotson
S. Ibbotson
中科院分区:
医学3区
文献类型:
--
作者:
J. So;S. Edwards;S. Ibbotson

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一名76岁的男子开始对卡马西平部分癫痫发作。随后出现皮疹,呈明显的光分布模式,发热、淋巴结病、嗜酸性粒细胞增多、肝功能检查异常和非典型淋巴细胞增多,符合药物诱导的超敏反应综合征的标准。停药卡马西平和应用局部类固醇导致皮疹清除,肝功能检查正常化和嗜酸性粒细胞增多症改善。光分布模式在这种情况下,卡马西平诱导的过敏综合征是有趣的。
A 76- year- old man was commenced on carbamazepine for partial seizures. This was followed by the development of a rash in an apparently photodistributed pattern, fever, lymphadenopathy, eosinophilia, abnormal liver function tests and atypical lymphocytosis fulfilling the criteria for drug-induced hypersensitivity syndrome. Discontinuation of carbamazepine and application of topical steroid resulted in clearance of the rash, normalization of liver function tests and improvement in eosinophilia. The photodistributed pattern in this case of carbamazepine-induced hypersensitivity syndrome is of interest.
与人类疱疹病毒多次再激活相关的氰胺引起的药物过敏综合征
DOI: --
发表时间: 2005
期刊: J Med Virol 75(3)
影响因子: --
作者:
福田治久;今中雄一;廣瀬昌博;林田賢史.;Mitani N
通讯作者: Mitani N