UNIMPAIRED THERMOGENIC RESPONSE TO NORADRENALINE IN GENETIC (OB/OB) AND HYPOTHALAMIC (MSG) OBESE MICE
UNIMPAIRED THERMOGENIC RESPONSE TO NORADRENALINE IN GENETIC (OB/OB) AND HYPOTHALAMIC (MSG) OBESE MICE
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DOI：
10.1007/bf01140498
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发表时间：
1984-01-01
影响因子：
4
通讯作者：
MILLER, DS
中科院分区：
文献类型：
--
作者：
DULOO, AG;MILLER, DS
在25 ℃下研究对去甲肾上腺素[去甲肾上腺素，NE]给药的产热反应。C在2种肥胖小鼠模型（QEC品系的遗传性ob/ob肥胖和谷氨酸单钠诱导的肥胖）及其各自的瘦同窝出生小鼠中。S.C.注射低剂量NE（100 μ g/kg体重）使两种肥胖模型的代谢率升高约30%，但在它们各自的瘦型对应物中没有。在注射高剂量NE（600 μ g/kg体重）后，代谢率的增加在瘦和肥胖动物中具有相似的幅度：代谢率增加70- 80%。在该QEC品系的ob/ob小鼠和下丘脑受损的肥胖小鼠中，整体全身产热能力在室温下未受损。因此，这些模型中的肥胖与对NE的反应能力降低无关，而可能是由于NE释放失败。
The thermogenic response to noradrenaline [norepinephrine, NE] administration was investigated at 25.degree. C in 2 models of obese mice (genetic ob/ob obesity of the QEC strain and monosodium-glutamate-induced obesity) and in their respective lean littermates. S.c. injections of a low dose of NE (100 .mu.g/kg body wt) elevated metabolic rate by about 30% in both obese models but not in their respective lean counterparts. The increase in metabolic rate after injections of a high dose of NE (600 .mu.g/kg body wt) was of a similar magnitude in both lean and obese animals: metabolic rate was increased by 70-80%. The overall whole body thermogenic capacity is unimpaired at room temperature in this QEC strain of ob/ob mice and in the hypothalamic damaged obese mice. Obesity in these models is therefore not associated with a reduced ability to respond to NE but could rather be due to a failure to release NE.