Nanopatterned polymer brushes as switchable bioactive interfaces.
Nanopatterned polymer brushes as switchable bioactive interfaces.
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DOI：
10.1039/c3nr00312d
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发表时间：
2013-04
期刊：
影响因子：
6.7
通讯作者：
Qian Yu;Phanindhar Shivapooja;L. Johnson;G. Tizazu;G. Leggett;G. López
中科院分区：
文献类型：
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作者：
Qian Yu;Phanindhar Shivapooja;L. Johnson;G. Tizazu;G. Leggett;G. López
我们报道了在大面积上合成纳米图案化的聚（N-异丙基丙烯酰胺）热响应刷的方便方法（例如，1cm（2））以形成模型、动态、生物功能表面。新的纳米图案化刷结构可用于控制（i）在基底的无聚合物接枝区域处的非特异性和生物特异性吸附过程的速率，以及（ii）细胞脱离的速率。这些能力在许多生物技术领域具有潜在的影响，包括生物传感、分离和细胞培养。
We report convenient methods for synthesis of nanopatterned, thermally responsive brushes of poly(N-isopropyl acrylamide) over large areas (e.g., 1 cm(2)) to form model, dynamic, biofunctional surfaces. The new nanopatterned brush structure can be used to control (i) the rate of both nonspecific and biospecific adsorption processes at the polymer-graft-free regions of the substrate, and (ii) the rate of cell detachment. These capabilities have potential implications in a number of areas of biotechnology including biosensing, separations and cell culture.