Synthesis and characterization of biodegradable thermosensitive poly(organophosphazene) gels
Synthesis and characterization of biodegradable thermosensitive poly(organophosphazene) gels
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DOI：
10.1021/ma0305838
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发表时间：
2004-06-15
期刊：
影响因子：
5.5
通讯作者：
Song, SC
中科院分区：
文献类型：
--
作者：
Lee, BH;Song, SC
合成了含α-氨基-欧米伽-甲基-聚乙二醇酯(AMPEG)、一些疏水氨基酸酯和作为水解性敏感部分的二氨基乙酸乙酯(乙二醇乙酯)的温敏性聚(有机磷腈)。合成的大部分聚(有机磷腈)在水溶液中具有溶胶-凝胶转变性质。聚合物的凝胶性能取决于取代基的组成、Ampeg的链长和氨基酸酯的种类。聚合物的凝胶化似乎是通过氨基酸酯疏水基团的缔合来实现的。聚合物在生理条件下分解。含有少量脱脂多肽的聚合物比不含脱脂多肽的聚合物的水解速度更快。聚合物凝胶的粘度也受降解率的影响。
Thermosensitive poly(organophosphazenes) bearing alpha-amino-omega-methyl-poly(ethylene glycol) (AMPEG), some hydrophobic amino acid esters, and a depsipeptide ethyl ester (ethyl-2-(O-glycyl)glycolate) as a hydrolysis-sensitive moiety have been synthesized. Most of the poly(organophosphazenes) synthesized showed sol-gel transition properties in an aqueous solution. The gelation properties of the polymers were dependent on several factors like the composition of substituents, the chain length of AMPEG, and kinds of amino acid esters. The gelation of the polymers seemed to be imparted by association of hydrophobic groups of amino acid esters. The polymers decomposed under the physiological conditions. The polymer with a small amount of depsipeptide was hydrolyzed more rapidly than that with no depsipeptide. The viscosity of the polymer gels was also affected by their degradation rate.