THE NATURAL-HISTORY OF HIV-1 INFECTION - STAGING CLASSIFICATIONS OF DISEASE
THE NATURAL-HISTORY OF HIV-1 INFECTION - STAGING CLASSIFICATIONS OF DISEASE
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DOI：
10.1097/00002030-199104000-00001
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发表时间：
1991-04-01
期刊：
影响因子：
3.8
通讯作者：
WINKELSTEIN, W
中科院分区：
文献类型：
--
作者：
ROYCE, RA;LUCKMANN, RS;WINKELSTEIN, W
我们在一个基于人群的队列中评估并比较了四种HIV感染的分期分类系统：（1）基于前驱临床标准的分期;（2）Walter Reed分期分类（WRSC）;（3）免疫学分期系统（ISS）;（4）基于口腔疾病和CD 4 + T细胞耗竭的简单分期。 该分期系统应用于旧金山弗朗西斯科男性健康研究队列中的386名HIV感染男性，这些男性在基线检查时没有艾滋病。 在48-56个月的随访后，确定每个阶段的艾滋病累积发病率和累积死亡率。 与其他系统不同，WRSC无法对相当大比例的艾滋病毒感染者（51.9%）进行分类。 WRSC和ISS包括一个或多个阶段，这些阶段似乎与与相邻阶段的预后基本不同无关。 基于CD 4 + T细胞耗竭和口腔疾病的简化分期系统可能是所研究的系统中最有效的。在HIV感染的演变过程中的病理生理学的更完整的理解将需要定义一个更详细的分期这种疾病。
We evaluated and compared four staging classification systems for HIV infection in a population-based cohort: (1) a staging based on prodromal clinical criteria; (2) the Walter Reed Staging Classification (WRSC); (3) the immunologic staging system (ISS), and (4) a simple staging based on oral disease and CD4+ T-cell depletion. The staging systems were applied to 386 HIV-infected men in the San Francisco Men's Health Study cohort who did not have AIDS at the baseline examination. After 48-56 months of follow-up the cumulative incidence of AIDS and the cumulative mortality by stage was determined for each staging. Unlike the other systems, the WRSC could not classify a substantial proportion of HIV-infected men (51.9%). The WRSC and ISS include one or more stages which did not appear to be associated with a prognosis substantially different from that of adjacent stages. The simplified staging system based on CD4+ T-cell depletion and oral disease may be the most effective of the systems studied. A more complete understanding of the pathophysiology during the evolution of HIV infection will be required to define a more detailed staging of this disease.