BIOLOGY OF TUMOR-METASTASIS
BIOLOGY OF TUMOR-METASTASIS
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DOI：
10.1016/0140-6736(92)92039-i
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发表时间：
1992-06-13
期刊：
影响因子：
168.9
通讯作者：
SAINI, A
中科院分区：
文献类型：
--
作者：
HART, IR;SAINI, A
尽管肿瘤转移具有重要的临床意义，但与早期肿瘤转化事件相比，实验室对其分子机制的研究较少。尽管如此，对基本细胞和分子特征的研究已经产生了一些发现，这些发现可能与我们对肿瘤传播的理解有关。将这些因素的重要性归因于肿瘤扩散的复杂性，以及肿瘤转移通常是肿瘤发展的晚期表现，这些都充满了困难。肿瘤进展的过程1意味着，由于许多基因的丢失、失活、突变或过度表达而引起的基因表达变化可能是多样和复杂的。
Despite the clinical importance of metastasis, laboratory studies on the molecular mechanisms responsible have been less numerous than those focused on the earlier event of neoplastic transformation. Nonetheless research on basic cellular and molecular characteristics has produced findings which could be relevant to our understanding of tumour dissemination. Attributing significance to these is fraught with difficulty, in part because of the complexity of tumour spread and in part because metastasis is often a late manifestation in tumour development. The process of tumour progression1 means that changes in gene expression, arising as a consequence of loss, inactivation, mutation, or overexpression of many genes, may be varied and complex.