The importance of CD25+CD4+ regulatory T cells in mouse hepatic allograft tolerance
The importance of CD25+CD4+ regulatory T cells in mouse hepatic allograft tolerance
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DOI：
10.1002/lt.20787
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发表时间：
2006-07-01
影响因子：
4.6
通讯作者：
Seino, Ken-ihiro
中科院分区：
文献类型：
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作者：
Jiang, Xiaofeng;Morita, Miwa;Seino, Ken-ihiro
在小鼠肝移植中，耐受性是容易诱导的。最近的研究表明，CD25(+)CD4（+）调节性T细胞在调节包括移植耐受在内的各种免疫反应中发挥重要作用。然而，这些细胞对小鼠肝移植耐受的贡献尚未阐明。我们在这里表明，CD25(+)CD4(+) T细胞的消耗增加了CD4(+) T细胞的增殖反应和CD8(+) T细胞的细胞毒性T淋巴细胞诱导。在肝移植前，这些细胞在受体体内耗竭而在供体体内没有耗竭引起排斥反应。此外，耐受小鼠的肝单核淋巴细胞CD25(+)CD4（+）群数量和叉头/翼螺旋转录因子表达高于排斥小鼠。综上所述，这些结果表明，肝移植受体而非供体的CD25(+)CD4（+）调节性T细胞在耐受诱导中起重要作用。
In mouse liver transplantation, tolerance is readily inducible. Recent studies have revealed that CD25(+)CD4(+) regulatory T cells play an important role in regulating various immune responses, including transplant tolerance. However, the contribution of these cells to tolerance in mouse liver transplantation has not been elucidated. We showed here that depletion of CD25(+)CD4(+) T cells increased proliferative response of CD4(+) T cells and cytotoxic T lymphocyte induction of CD8(+) T cells. Depletion of these cells in the recipient but not in the donor before liver transplantation caused rejection. Furthermore, the number of CD25(+)CD4(+) population and forkhead/winged helix transcription factor expression in liver mononuclear lymphocytes derived from tolerant mice were higher than those from grafts undergoing rejection. In conclusion, these results indicate that CD25(+)CD4(+) regulatory T cells in the recipient but not in the donor of liver transplantation are important for the tolerance induction.