Improved High-Fat Diet-Induced Glucose Intolerance by an Oral Administration of Phytosphingosine
Improved High-Fat Diet-Induced Glucose Intolerance by an Oral Administration of Phytosphingosine
复制标题
DOI：
10.1271/bbb.120644
复制
发表时间：
2013-01-01
影响因子：
1.6
通讯作者：
Igarashi, Yasuyuki
中科院分区：
文献类型：
--
作者：
Murakami, Itsuo;Mitsutake, Susumu;Igarashi, Yasuyuki
我们以前曾报道，植物神经酰胺和植物鞘氨醇（PHS）刺激细胞中过氧化物酶体增殖物激活受体γ（PPAR γ）的转录活性。PPAR γ是2型糖尿病的治疗靶点。我们在这项研究中发现，口服PHS改善了小鼠饮食诱导的葡萄糖耐受不良。由于PHS在酵母中高度表达，发酵食品中的PHS可能会改善糖尿病。
We have previously reported that phytoceramide and phytosphingosine (PHS) stimulated the transcriptional activity of peroxisome proliferator-activated receptor gamma (PPAR gamma) in cells. PPAR gamma is a therapeutic target for type 2 diabetes. We found in this study that an oral administration of PHS improved diet-induced glucose intolerance in mice. Since PHS is highly expressed in yeast, PHS in fermented foods may improve diabetes.