A Randomized Clinical Trial of Cognitive-Behavioral Therapy for Insomnia to Augment Posttraumatic Stress Disorder Treatment in Survivors of Interpersonal Violence.

A Randomized Clinical Trial of Cognitive-Behavioral Therapy for Insomnia to Augment Posttraumatic Stress Disorder Treatment in Survivors of Interpersonal Violence.
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认知行为疗法治疗失眠以增强人际暴力幸存者创伤后应激障碍治疗的随机临床试验。

DOI:
10.1159/000517862
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发表时间:
2022
影响因子:
22.8
通讯作者:
Heffner KL
Heffner KL
中科院分区:
医学1区
文献类型:
--
作者:
Pigeon WR;Crean HF;Cerulli C;Gallegos AM;Bishop TM;Heffner KL

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Individuals exposed to interpersonal violence (IPV) commonly develop posttraumatic stress disorder (PTSD) with co-occurring depression and insomnia. Standard PTSD interventions such as cognitive processing therapy (CPT) do not typically lead to remission or to improved insomnia. Cognitive behavioral therapy for insomnia (CBTi) improves insomnia in individuals with PTSD, but PTSD severity remains elevated. Determine whether sequential treatment of insomnia and PTSD is superior to treating only PTSD. In a 20-week trial, 110 participants exposed to IPV who had PTSD, depression and insomnia were randomized to CBTi followed by CPT or to attention control followed by CPT. Primary outcomes following CBTi (or Control) were 6-week change in score on the Insomnia Severity Index (ISI), Clinician-Administered PTSD Scale (CAPS), and Hamilton Rating Scale for Depression (HAM-D). Primary outcomes following CPT were the 20-week change in scores. At 6 weeks, the CBTi condition had greater reductions in ISI, HAM-D and CAPS scores than the attention control condition. At 20 weeks, participants in the CBTi+CPT condition had greater reductions in ISI, HAM-D and CAPS scores compared to Control+CPT. Effects were larger for insomnia and for depression than for PTSD. Similar patterns were observed with respect to clinical response and remission. A tipping point sensitivity analyses supported the plausibility of findings. The sequential delivery of CBTi and CPT had plausible, significant effects on insomnia, depression and PTSD compared to CPT alone. Effects for PTSD symptoms were moderate and clinically meaningful.
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