Exploring the cytokine and endocrine involvement in narcolepsy
Exploring the cytokine and endocrine involvement in narcolepsy
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DOI：
10.1016/j.bbi.2003.11.002
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发表时间：
2004-07-01
影响因子：
15.1
通讯作者：
Coussons-Read, ME
中科院分区：
文献类型：
--
作者：
Okun, ML;Giese, S;Coussons-Read, ME
发作性睡病是一种致残性神经睡眠障碍，其特征是白天过度嗜睡和异常REM睡眠表现。最近，细胞因子和生长激素在睡眠和发作性睡病的调节中的作用已被考虑，并且数据表明促炎细胞因子可能参与睡眠和发作性睡病症状。从斯坦福大学发作性睡病研究中心获得39名发作性睡病患者（22名女性，17名男性，年龄39 ± 14.9）和40名对照（13名女性，27名男性，年龄46 ± 17.9）的血清和临床数据。通过ELISA测量TNF-α、IL-6和人生长激素（hGH）的血浆水平。与对照组相比，发作性睡病受试者的TNF-α和IL-6显著升高（p <0.001）。有趣的是，在发作性睡病受试者中hGH显著增加（p < .0001）。埃普沃思嗜睡量表（ESS）也有显著差异（17.7 +/- 4.6 vs. 5.5 +/- 3.2，p <0.0001）。这些数据表明，发作性睡病，相对于对照组，有较高的血清水平的TNF-α，IL-6，和hGH。这些数据表明，发作性睡病患者中观察到的睡眠失调与这些受试者中观察到的免疫和内分泌失调相关，观察到的变化实际上可能导致睡眠紊乱和/或感染发生率增加的可能性更高。需要更多的工作来充分表征细胞因子和发作性睡病之间的联系。(C)2004爱思唯尔公司All rights reserved.
Narcolepsy is a disabling neurological sleep disorder characterized by excessive daytime sleepiness and abnormal REM sleep manifestations. Recently, the role of cytokines and growth hormone in the regulation of sleep and narcolepsy has been considered, and data suggest that proinflammatory cytokines may be involved in sleep and narcoleptic symptoms. Serum and clinical data were obtained from the Stanford Center for Narcolepsy Research for 39 Narcoleptics (22 Females, 17 Males, age 39 +/- 14.9) and 40 controls (13 Females, 27 Males, age 46 +/- 17.9). Plasma levels of TNF-alpha, IL-6, and human growth hormone (hGH) were measured by ELISA. TNF-alpha and IL-6 were significantly increased in narcoleptic subjects compared to controls (p < .001). Interestingly, hGH was significantly increased in narcoleptic subjects (p < .0001). There was also a significant difference in the epworth sleepiness scale (ESS) (17.7 +/- 4.6 vs. 5.5 +/- 3.2, p < .0001). These data indicate that narcoleptics, relative to controls, had higher serum levels of TNF-alpha, IL-6, and hGH. These data suggest that the dysregulation of sleep observed in narcoleptics correlates with the immune and endocrine dysregulation seen in these subjects, and the observed changes may in fact contribute to the higher likelihood of disturbed sleep and/or increased incidence of infection. Additional work is required to fully characterize connections between cytokines and narcoleptic symptomatology. (C) 2004 Elsevier Inc. All rights reserved.