Melatonin and female reproduction
Melatonin and female reproduction
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DOI：
10.1111/jog.12177
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发表时间：
2014-01-01
影响因子：
1.6
通讯作者：
Sugino, Norihiro
中科院分区：
文献类型：
--
作者：
Tamura, Hiroshi;Takasaki, Akihisa;Sugino, Norihiro
褪黑激素（N-乙酰基-5-甲氧基色胺）在夜间黑暗时由松果体分泌。褪黑激素进入循环后，作为内分泌因子和光与暗的化学信使。它调节与昼夜节律和生殖有关的各种重要的中枢和外周活动。它还影响大脑、免疫、胃肠道、心血管、肾脏、骨骼和内分泌功能，并作为一种抑瘤和抗衰老分子。褪黑激素的许多作用是通过与不仅在中枢神经系统中表达，而且在外周组织中表达的特异性膜结合受体的相互作用来介导的。褪黑激素还通过非受体介导的机制起作用，例如充当活性氧物质和活性氮物质的清除剂。在生理和药理浓度下，褪黑激素减弱和抵消氧化应激并调节细胞代谢。越来越多的生殖生理学科学证据支持褪黑激素在人类生殖中的作用。本文就褪黑激素对雌性生殖的影响作一综述。
Melatonin (N-acetyl-5-methoxytryptamine) is secreted during the dark hours at night by the pineal gland. After entering the circulation, melatonin acts as an endocrine factor and a chemical messenger of light and darkness. It regulates a variety of important central and peripheral actions related to circadian rhythms and reproduction. It also affects the brain, immune, gastrointestinal, cardiovascular, renal, bone and endocrine functions and acts as an oncostatic and anti-aging molecule. Many of melatonin's actions are mediated through interactions with specific membrane-bound receptors expressed not only in the central nervous system, but also in peripheral tissues. Melatonin also acts through non-receptor-mediated mechanisms, for example serving as a scavenger for reactive oxygen species and reactive nitrogen species. At both physiological and pharmacological concentrations, melatonin attenuates and counteracts oxidative stress and regulates cellular metabolism. Growing scientific evidence of reproductive physiology supports the role of melatonin in human reproduction. This review was conducted to investigate the effects of melatonin on female reproduction and to summarize our findings in this field.