Dynamic combinatorial chemistry: on the road to fulfilling the promise
Dynamic combinatorial chemistry: on the road to fulfilling the promise
复制标题
DOI：
10.1039/b714599c
复制
发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Ladame, Sylvain
中科院分区：
文献类型：
--
作者：
Ladame, Sylvain
动态组合化学利用官能化单体结构单元之间的可逆反应，在热力学平衡下产生产物的混合物（二聚体或低聚物）。该系统在添加靶时重组，使得结合到靶并因此被靶稳定的物质有利地形成并因此被扩增。自20世纪90年代中期以来，动态组合化学已成功地应用于离子受体、酶抑制剂、催化剂、材料和核酸配体的鉴定/选择。虽然它现在被确立为具有广泛应用的强大工具，但在处理日益复杂的系统时出现了一些内在的局限性。我们在这里介绍了动态组合化学领域的最新进展，这些进展是为了克服这些限制并探索新的应用领域而开发的。
Dynamic combinatorial chemistry makes use of reversible reactions between functionalised monomeric building blocks to generate a mixture of products (dimers or oligomers) under thermodynamic equilibrium. This system reorganises upon addition of a target so that species that bind to, and are therefore stabilised by the target, are favourably formed and are thus amplified. Since the mid-1990's, dynamic combinatorial chemistry has been successfully applied to the identification/selection of ion receptors, enzyme inhibitors, catalysts, materials and nucleic acid ligands. Although it is now established as a powerful tool with broad applications some intrinsic limitations appeared when working on systems of increasing complexity. We present here the most recent advances in the field of dynamic combinatorial chemistry that have been developed to overcome these limitations and explore new areas of application.