The evaluation of endothelial function with flow-mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary syndrom patients; existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function
The evaluation of endothelial function with flow-mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary syndrom patients; existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function
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DOI：
10.1016/j.fertnstert.2007.11.057
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发表时间：
2009-02-01
影响因子：
6.7
通讯作者：
Gokalp, Deniz
中科院分区：
文献类型：
--
作者：
Arikan, Senay;Akay, Hatice;Gokalp, Deniz
目的：评价年轻非肥胖型多囊卵巢综合征（PCOS）患者血管内皮功能与血流介导扩张（FMD）及颈动脉内膜中膜厚度（IMT）的关系。设计：前瞻性病例对照研究。研究对象：临床研究中的健康志愿者和非肥胖青年多囊卵巢综合征患者。患者：39例PCOS患者，平均年龄22.82±5.53岁，30例体重指数和年龄匹配的健康对照。干预：采用曲线下面积、定量胰岛素敏感性检查、松田指数计算胰岛素抵抗。采用FMD和颈动脉IMT超声检查内皮功能。主要观察指标：测定心率、激素、生化指标（胰岛素、血糖、肿瘤坏死因子- α、hs-c反应蛋白、同型半胱氨酸水平等）、FMD、IMT。结果：多囊卵巢综合征患者存在明显的胰岛素抵抗。PCOS患者血清FSH、总睾酮和游离睾酮、皮质醇、雄烯二酮和DHEA-S水平均高于对照组，但FMD测定的内皮功能未见显著差异。结论：单独存在胰岛素抵抗可能不是导致年轻非肥胖PCOS患者内皮功能和颈动脉IMT恶化的充分因素。其他因素，如胰岛素抵抗的持续时间、年龄、肥胖和炎症标志物可能在这一过程中发挥重要作用。[j] .中国农业科学（英文版），2009;31(1):1 -5。(C)2009年美国生殖医学学会。)
Objective: To evaluate endothelial function with flow-mediated dilatation (FMD) and carotid intima media thickness (IMT) in young nonobese polycystic ovary syndrome (PCOS) patients.Design: Prospective case-control study.Setting: Healthy volunteers and nonobese young PCOS patients in clinical research.Patient(s): Thirty-nine PCOS patients with mean age of 22.82 +/- 5.53 years and 30 body mass index- and age-matched healthy controls were evaluated.Intervention(s): Insulin resistance was calculated with area under the curve, quantitative insulin sensitivity check, and the Matsuda index. Endothelial function was assessed with FMD and carotid IMT by ultrasonography.Main Outcome Measure(s): Antropometric, hormonal, biochemical (insulin and glucose, tumor necrosis factor-alpha, hs-c-reactive protein, and homocysteine levels, and so forth), FMD, and IMT were measured.Result(s): There was a significant insulin resistance in PCOS patients. Serum FSH, total and free testosterone, cortisol, androstenedione, and DHEA-S levels of PCOS patients were also higher than control subjects, but we could not find any significant difference in terms of endothelial function determined with FMD.Conculsion(s): Existence of insulin resistance alone may not bean adequate factor for deterioration of endothelial function and carotid IMT in young, nonobese patients with PCOS. Other factors such as duration of insulin resistance, older age, presence of obesity, and inflammatory markers may play an important role in this process. (Fertil Steril (R) 2009;91:450-5. (C)2009 by American Society for Reproductive Medicine.)