Blood pressure and its reactivity in the offspring of first cousin hypertensive and first cousin normotensive parents: a preliminary report
Blood pressure and its reactivity in the offspring of first cousin hypertensive and first cousin normotensive parents: a preliminary report
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DOI：
10.1038/sj.jhh.1001284
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发表时间：
2001-12-01
影响因子：
2.7
通讯作者：
Ziada, A
中科院分区：
文献类型：
--
作者：
Hassan, MO;Al Kharusi, W;Ziada, A
这项初步研究的目的是确定与血压正常的表亲父母的后代相比，表亲高血压父母的年轻后代是否对他们的第一次血压测量有更高的血压反应性。135名9-10岁的男孩的血压测量，首次，仰卧休息10分钟后，随后，两次在10分钟的间隔。在所有三项测量中，高血压父母的第一堂兄弟姐妹的后代的收缩压和舒张压均显著高于血压正常的第一堂兄弟姐妹的后代。这项研究表明，在早期的年龄，第一堂兄弟姐妹高血压的父母，反应与夸大的血压反应，在他们的第一次偶然的血压测量。我们推测，高血压的家族聚集性可能在高血压父母近亲结婚的后代中表现出更多的表达。
The aim of this preliminary study was to determine whether young offspring of first cousin hypertensive parent(s), have higher blood pressure (BP) reactivity in response to their first BP measurement, as compared to the offspring of first cousin normotensive parents. The BP of 135 boys aged 9-10 years was measured, for the first time ever, after a 10-min supine rest, and subsequently, twice at 10-min intervals. The offspring of first cousin hypertensive parent(s) reacted with significantly higher systolic and diastolic BP than the offspring of normotensive first cousin parents in all three measurements. This study indicates that at an early age, the offspring of first cousin hypertensive parents, react with exaggerated BP response at their first casual BP measurement. We hypothesise that familial aggregation of BP may show more expression amongst the offspring of consanguineous marriage of hypertensive parent(s).