Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia.
Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia.
复制标题
DOI：
10.3109/15622975.2014.948063
复制
发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Mulert C
中科院分区：
文献类型：
--
作者：
Wigand M;Kubicki M;Clemm von Hohenberg C;Leicht G;Karch S;Eckbo R;Pelavin PE;Hawley K;Rujescu D;Bouix S;Shenton ME;Mulert C
大脑半球间听觉通路在听觉刺激的处理过程中起着重要作用，双侧听觉区之间结构和功能连接的改变可能与听觉言语幻觉（AVH）的发病机制有关。本研究的目的是检查这一途径在慢性精神分裂症患者的AVH的终身史。DTI扫描采集自33名健康对照（HC）、24名有AVH病史的精神分裂症患者（LT-AVH）和9名无任何终生幻觉的精神分裂症患者（N-LT-AVH）。采用流线型纤维束成像技术提取大脑纵裂听纤维束。随后，计算扩散系数指数，即分数各向异性（FA），微量，模式，轴向和径向扩散。与N-LT-AVH相比，LT-AVH的FA在整个通路上均降低。此外，LT-AVH显示减少FA和模式，以及增加径向扩散率在正中矢状面的纤维束。这些研究结果表明，复杂的微结构的变化，在大脑半球间的听觉通路的精神分裂症患者的历史AVH。在从未产生过幻觉的患者中似乎不存在这种变化。
The interhemispheric auditory pathway has been shown to play a crucial role in the processing of acoustic stimuli, and alterations of structural and functional connectivity between bilateral auditory areas are likely relevant to the pathogenesis of auditory verbal hallucinations (AVHs). The aim of this study was to examine this pathway in patients with chronic schizophrenia regarding their lifetime history of AVHs. DTI scans were acquired from 33 healthy controls (HC), 24 schizophrenia patients with a history of AVHs (LT-AVH) and 9 schizophrenia patients without any lifetime-hallucinations (N-LT-AVH). The interhemispheric auditory fibre bundles were extracted using streamline tractography. Subsequently, diffusivity indices, namely Fractional Anisotropy (FA), Trace, Mode, Axial and Radial Diffusivity, were calculated. FA was decreased over the entire pathway in LT-AVH compared with N-LT-AVH. Moreover, LT-AVH displayed decreased FA and Mode as well as increased Radial Diffusivity in the midsagittal section of the fibre tract. These findings indicate complex microstructural changes in the interhemispheric auditory pathway of schizophrenia patients with a history of AVHs. Alterations appear to be absent in patients who have never hallucinated.