Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment.
Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment.
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DOI：
10.7554/elife.85140
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发表时间：
2023-03-14
期刊：
影响因子：
7.7
通讯作者：
Marti M
中科院分区：
文献类型：
--
作者：
Abdi AI;Achcar F;Sollelis L;Silva-Filho JL;Mwikali K;Muthui M;Mwangi S;Kimingi HW;Orindi B;Andisi Kivisi C;Alkema M;Chandrasekar A;Bull PC;Bejon P;Modrzynska K;Bousema T;Marti M
疟疾寄生虫的生命周期包括在人类血液中的无性复制，其中一部分寄生虫分化为传播给蚊子所需的配子体。承诺分化成配子母细胞，这是由寄生虫转录因子ap 2-g的激活为标志，是已知的宿主因素的影响，但一个全面的模型仍然不确定。在这里，我们分析了来自肯尼亚基利菲828名儿童的数据，这些儿童在疟疾传播下降的18年中患有严重，简单和无症状的疟疾感染。我们研究宿主免疫和代谢的标志物，以及寄生虫生长和传播投资的标志物。我们发现，与血浆溶血磷脂酰胆碱水平降低相关的炎症反应与寄生虫有性生殖投资增加（即传播投资）和生长减少（即无性复制）的标志物相关。随着传播率的下降，这种关联变得更强，这表明寄生虫可以对宿主内环境迅速做出反应，而宿主内环境反过来又会受到传播率变化的影响。
The malaria parasite life cycle includes asexual replication in human blood, with a proportion of parasites differentiating to gametocytes required for transmission to mosquitoes. Commitment to differentiate into gametocytes, which is marked by activation of the parasite transcription factor ap2-g, is known to be influenced by host factors but a comprehensive model remains uncertain. Here, we analyze data from 828 children in Kilifi, Kenya with severe, uncomplicated, and asymptomatic malaria infection over 18 years of falling malaria transmission. We examine markers of host immunity and metabolism, and markers of parasite growth and transmission investment. We find that inflammatory responses associated with reduced plasma lysophosphatidylcholine levels are associated with markers of increased investment in parasite sexual reproduction (i.e. transmission investment) and reduced growth (i.e. asexual replication). This association becomes stronger with falling transmission and suggests that parasites can rapidly respond to the within-host environment, which in turn is subject to changing transmission.
影响因子：
4.6
作者：
Huang DT;Lu CY;Chi YH;Li WL;Chang LY;Lai MJ;Chen JS;Hsu WM;Huang LM
通讯作者：
Huang LM
影响因子：
4.4
作者：
Kearney, Staci;Delgado, Christine;Lenz, Laurel L.
通讯作者：
Lenz, Laurel L.