Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans
Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans
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DOI：
10.1007/bf03343763
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发表时间：
2000-09-01
影响因子：
5.4
通讯作者：
Ghigo, E
中科院分区：
文献类型：
--
作者：
Arvat, E;Di Vito, L;Ghigo, E
生长激素促分泌素受体（GHS - R）的一种内源性配体最近从大鼠和人的胃中被纯化出来，并被命名为胃饥饿素。已经证明胃饥饿素能特异性地刺激培养的大鼠垂体细胞以及体内大鼠的生长激素分泌。在这项初步研究中，对4名正常成年人[年龄（均值±标准误）：28.6±3.5岁；体重指数（BMI）：22.3±2.1 kg/m²]，我们给予1.0μg/kg胃饥饿素或生长激素释放激素 - 29，以比较它们在人体内的生长激素释放活性。在所有受试者中，胃饥饿素引起循环生长激素水平迅速、显著且持久的升高（峰值：107.9±26.1μg/L；曲线下面积：6503.1±1632.7μg/L·h）。对胃饥饿素的生长激素反应明显更高（p<...此处原文似乎不完整）
An endogenous ligand for the GH secretagogue-receptor (GHS-R) has been recently purified from rat and human stomach and named Ghrelin, It has been demonstrated that Ghrelin specifically stimulates GH secretion from rat pituitary cells in culture as well as in rats in vivo. In this preliminary study, in 4 normal adults Cage (mean+/-SE): 28.6+/-3.5 yr; body mass index (BMI): 22.3+/-2.1 kg/m(2)] we administered 1.0 mu g/kg Ghrelin or GHRH-29 to compare their GH-releasing activities in humans, In all subjects Ghrelin induced a prompt, marked and long-tasting increase in circulating GH levels(peak: 107.9+/-26.1 mu g/l; AUG: 6503.1+/-1632.7 mu g/l/h). The GH response to Ghrelin was clearly higher (p