Serum lactate levels are associated with glioma malignancy grade
Serum lactate levels are associated with glioma malignancy grade
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DOI：
10.1016/j.clineuro.2019.105546
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发表时间：
2019-11-01
影响因子：
1.9
通讯作者：
Vaz, Rui
中科院分区：
文献类型：
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作者：
Branco, Mariana;Linhares, Paulo;Vaz, Rui
目的：最近的研究表明，高级别胶质瘤与血清乳酸浓度升高有关。患者和方法：我们回顾了接受手术的低级别和高级别胶质瘤患者的麻醉图，并在肿瘤切除前收集了血清乳酸浓度，以及其他与人口统计学和肿瘤相关的数据(年龄、性别、WHO分级和肿瘤大小)。结果：共纳入152例患者，平均年龄49.07岁。高级别胶质瘤占62.5%(n=95)，低级别胶质瘤占37.5%(n=67)。多因素回归分析显示，高级别胶质瘤的乳酸浓度显著高于正常组(p<；0.01)。调整年龄和术前糖皮质激素使用后，术前血乳酸升高的OR从4.94增加到14.33，最终回归模型的AUC为0.98。结论：本研究加强了血乳酸作为脑肿瘤恶性的潜在生物标志物的作用，其结果鼓励了对这一问题的进一步研究，以提高对这一现象的认识，并评估其作为预后和治疗监测工具的潜力。
Objective: Recent studies have suggested that high grade gliomas are associated with elevated serum lactate concentrations. The aim of the present study is to assess these findings in a sample of patients.Patients and methods: We reviewed the anesthetic charts of patients with low-grade and high-grade glioma who underwent resection surgery and collected serum lactate concentration before tumor resection, as well as other demographic and tumor-related data (age, gender, WHO grade, and size of the tumor). A statistical comparison between patients with normal (< 2 mmol/L) and elevated ( 2 mmol/L) serum lactate was performed.Results: We included a total of 152 patients (mean age 49.07 years). 62.5% of patients (n = 95) had a high-grade glioma and 37.5% (n = 67) a low-grade glioma. The multivariate regression showed that high grade gliomas had significantly higher lactate concentration (p < 0.01). The OR for elevated pre-resection serum lactate increased from 4.94 to 14.33 after adjusting for age and pre-surgical corticosteroid use, and the AUC for the final regression model was 0.98.Conclusion: This study reinforces the role of serum lactate as a potential biomarker of brain tumors malignancy, and its results encourage further research on this subject, in order to improve the understanding of this phenomenon and to assess its potential as prognostic and therapeutic monitoring tool.