Cigarette smoking and the risk of primary Sjögren's syndrome: a nested case control study.
Cigarette smoking and the risk of primary Sjögren's syndrome: a nested case control study.
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DOI：
10.1186/s13075-017-1255-7
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发表时间：
2017-03-07
影响因子：
4.9
通讯作者：
Theander E
中科院分区：
文献类型：
--
作者：
Olsson P;Turesson C;Mandl T;Jacobsson L;Theander E
据报道，吸烟会影响一些慢性疾病的风险，包括风湿性疾病。以前的横断面研究表明，原发性干燥综合征（pSS）患者的吸烟频率较低。本研究的目的是通过巢式病例对照研究，探讨吸烟和社会经济地位对pSS后续诊断风险的影响。通过与马尔默舍格伦综合征登记处的联系，确定了两项大型基于人群的健康调查的参与者，他们后来被诊断为pSS。从健康调查中获得匹配的对照。63例pSS患者的诊断前数据从健康调查确定。目前吸烟与以后诊断为pSS的风险显著降低相关（比值比（OR）0.3; 95% CI 0.1-0.6）。此外，与从不吸烟相比，既往吸烟与后续pSS诊断风险增加相关（OR 4.0; 95% CI 1.8-8.8）。在纳入健康调查后报告症状发作的患者的子分析中发现了类似的结果。社会经济地位和正规教育水平对后来被诊断为pSS的风险没有显着影响。在这项巢式病例对照研究中，目前吸烟与随后诊断为pSS的风险降低相关。此外，以前吸烟与风险增加有关。这是否反映了吸烟的生物学效应或其他机制，应在未来的研究中进一步调查。
Smoking is reported to affect the risk of a number of chronic disorders, including rheumatic diseases. Previous cross-sectional studies have shown a lower frequency of smoking in patients with primary Sjögren’s syndrome (pSS). The aim of this study was to investigate the impact of smoking and socioeconomic status on the risk of subsequent diagnosis of pSS in a nested case-control study. Participants in two large population-based health surveys who were later diagnosed with pSS were identified through linkage with the Malmö Sjögren’s Syndrome Register. Matched controls were obtained from the health surveys. Sixty-three patients with pSS with pre-diagnostic data from the health surveys were identified. Current smoking was associated with a significantly lower risk of later being diagnosed with pSS (odds ratio (OR) 0.3; 95% CI 0.1–0.6). Furthermore, former smoking was associated with an increased risk of subsequent pSS diagnosis (OR 4.0; 95% CI 1.8–8.8) compared to never smoking. Similar results were found in a sub-analysis of patients with reported symptom onset after inclusion in the health surveys. Socioeconomic status and levels of formal education had no significant impact on the risk of later being diagnosed with pSS. In this nested case-control study, current smoking was associated with a reduced risk of subsequent diagnosis of pSS. In addition, former smoking was associated with an increased risk. Whether this reflects a biological effect of cigarette smoking or other mechanisms should be further investigated in future studies.