Heritability of neck pain: a population-based study of 33 794 Danish twins
Heritability of neck pain: a population-based study of 33 794 Danish twins
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DOI：
10.1093/rheumatology/kei224
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发表时间：
2006-05-01
期刊：
影响因子：
5.5
通讯作者：
Kyvik, KO
中科院分区：
文献类型：
--
作者：
Fejer, R;Hartvigsen, J;Kyvik, KO
目标。在一项基于人群的双胞胎大规模研究中，确定颈部疼痛的遗传度。使用了丹麦双胞胎人口横断面调查中关于颈部疼痛终生患病率的数据。为了评估双胞胎的相似性，计算并比较了同卵双胞胎和异卵双胞胎的概率符合率、合子特异性优势比和四色相关性。使用生物统计学模型(结构方程模型)，估计了遗传和环境因素对颈部疼痛的影响。共有33794对双胞胎(应答率73%)回答了有关颈部疼痛的问题。前向符合率、特定合子优势比和四心率相关性显示了显著的遗传效应对颈部疼痛的影响。总的加性遗传成分为44%。遗传效应随年龄增长而递减，在年龄最大的男性组中仅占10%，在年龄最大的女性组中为0%。男性和女性的遗传度差异有统计学意义(34vs52%，P<；0.0001)。基因在颈部疼痛中起着重要作用，尤其是在女性身上。然而，随着年龄的增长，遗传因素的影响逐渐变得不那么重要，环境因素几乎完全在老年群体中占据主导地位。
Objectives. To determine the heritability of neck pain in a large population-based study of twins.Methods. Data on lifetime prevalence of neck pain from a population-based cross-sectional survey of Danish twins were used. To assess twin similarity, the probandwise concordance rates, zygosity-specific odds ratios and tetrachoric correlations were calculated and compared for monozygotic and dizygotic twins. Using biometric modelling (structural equation modelling), the genetic and environmental contributions of the liability to neck pain were estimated.Results. A total of 33 794 twins (response rate 73%) answered the questions regarding neck pain. Probandwise concordance rates, zygosity-specific odds ratios and tetrachoric correlations showed a significant genetic effect on neck pain. An overall additive genetic component of 44% was found. The genetic effect decreased with age, accounting for only 10% in the oldest male group and 0% in the oldest female group. There was a statistically significant difference in heritability between males and females (34 vs 52%, P < 0.0001).Conclusions. Genes play a significant role in neck pain, particularly in women. However, the genetic influence becomes gradually less important with increasing age, and environmental factors dominate almost completely in the older age groups.