Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats?
Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats?
复制标题
DOI：
10.1097/00006676-200310000-00011
复制
发表时间：
2003-10-01
期刊：
影响因子：
2.9
通讯作者：
Matsuno, S
中科院分区：
文献类型：
--
作者：
Mikami, Y;Takeda, K;Matsuno, S
前言：大分子肝素被认为在导致全身炎症反应的事件中起重要作用。一些是已知的，居住在腹腔，但没有报告定义参与的腹膜巨噬细胞（PMs）在急性pancreatitis.Aim的进展：为了澄清的作用PMs在急性pancreatitis.Methodology：急性胰腺炎的进展诱导大鼠从其中巨噬细胞以外的PMs大大耗尽，并在大鼠中大大耗尽巨噬细胞，包括PMs。通过注射包封二氯亚甲基二膦酸酯的脂质体来消耗大分子化合物。在诱导急性胰腺炎后，比较两组胰腺局部炎症、腹腔内炎症及肺损伤情况。然而，腹膜内炎症明显改善了PMs的消耗。血清细胞因子水平和肺损伤也得到改善的PMs.Conclusion：腹腔巨噬细胞扩大炎症从胰腺到腹腔，随后诱导急性胰腺炎肺损伤。腹腔巨噬细胞在大鼠急性胰腺炎的全身炎症反应和进展中起重要作用。
Introduction: Macrophages are considered to play an essential role in the events leading to systemic inflammatory response. Some are known to reside in the peritoneal cavity but there are no reports defining the participation of peritoneal macrophages (PMs) in the progression of acute pancreatitis.Aim: To clarify the role of PMs in the progression of acute pancreatitis.Methodology: Acute pancreatitis was induced in rats from which macrophages other than PMs were greatly depleted, and in rats greatly depleted of macrophages including PMs. Macrophages were depleted by the injection of liposome encapsulated dichloromethylene bisphosphonate. After the induction of acute pancreatitis, local pancreatic inflammation, intraperitoneal inflammation and lung injury were compared between the 2 groups.Results: Local pancreatic inflammation did not differ between the 2 groups. However, intraperitoneal inflammation was clearly improved by the depletion of PMs. Serum cytokine level and lung injury were also improved by the depletion of PMs.Conclusion: Peritoneal macrophages extend inflammation from the pancreas to the peritoneal cavity and subsequently induce lung injury in acute pancreatitis. Peritoneal macrophages play an essential role in the systemic inflammatory response and the progression of acute pancreatitis in the rat.