Tissue Engineering in Periodontal Tissue
Tissue Engineering in Periodontal Tissue
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DOI：
10.1002/ar.22812
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发表时间：
2014-01-01
影响因子：
2
通讯作者：
Okano, Teruo
中科院分区：
文献类型：
--
作者：
Iwata, Takanori;Yamato, Masayuki;Okano, Teruo
牙周炎是一种世界公认的疾病，是细菌感染引起的牙周组织炎症，导致牙槽骨丢失。一旦发生，即使进行去污治疗，受损的组织也无法恢复到原来的形式。半个多世纪以来，人们一直致力于研究真正的牙周再生。牙周膜再生是指对受损附着体的完全重建，包括硬组织（牙槽骨和牙骨质）和软组织（牙周膜）。几种治疗方法，包括骨移植、具有上皮细胞物理屏障的引导组织再生和生长因子，已被批准用于临床;然而，其适应症和结局有限。为了克服这些局限性，组织工程的概念被引入。已经在实验动物模型中研究了使用细胞、生长因子和支架的组合治疗，并且一些研究已经转化为临床试验。在这篇综述中，我们重点介绍了近年来的组织工程研究进展，并讨论了牙周再生的未来前景。Anat Rec，297：16-25. 2014. (c)2013 Wiley Periodicals，Inc.
Periodontitis, a recognized disease worldwide, is bacterial infection-induced inflammation of the periodontal tissues that results in loss of alveolar bone. Once it occurs, damaged tissue cannot be restored to its original form, even if decontaminating treatments are performed. For more than half a century, studies have been conducted to investigate true periodontal regeneration. Periodontal regeneration is the complete reconstruction of the damaged attachment apparatus, which contains both hard tissue (alveolar bone and cementum) and soft tissue (periodontal ligament). Several treatments, including bone grafts, guided tissue regeneration with physical barriers for epithelial cells, and growth factors have been approved for clinical use; however, their indications and outcomes are limited. To overcome these limitations, the concept of tissue engineering was introduced. Combination treatment using cells, growth factors, and scaffolds, has been studied in experimental animal models, and some studies have been translated into clinical trials. In this review, we focus on recent progressive tissue engineering studies and discuss future perspectives on periodontal regeneration. Anat Rec, 297:16-25. 2014. (c) 2013 Wiley Periodicals, Inc.