A Cell-Phone-Based Acoustofluidic Platform for Quantitative Point-of-Care Testing.
A Cell-Phone-Based Acoustofluidic Platform for Quantitative Point-of-Care Testing.
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DOI：
10.1021/acsnano.9b08349
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发表时间：
2020-03
期刊：
影响因子：
17.1
通讯作者：
Liying Zhang;Zhenhua Tian;Hunter Bachman;Peiran Zhang;T. Huang
中科院分区：
文献类型：
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作者：
Liying Zhang;Zhenhua Tian;Hunter Bachman;Peiran Zhang;T. Huang
声流体方法具有设备设计简单、生物相容性操作和低功耗等优点，被吹捧为有前途的即时检测工具。在这里，我们报告了一种基于手机的声流控平台，该平台利用声辐射力来丰富纳米级分析物和红色和绿色荧光纳米颗粒（SiO2@R和G@SiO2）作为POC视觉测试的探针。因此，来自荧光探针的颜色信号得到增强，比色灵敏度显著提高。作为POC演示，声流控平台用于检测人体血液中的血红蛋白（Hb），从而快速直接地测量正常血液中的血红蛋白水平。结合基于声流体的纳米颗粒浓度平台和基于手机的比色法，我们的方法为实际的POC测试提供了一条潜在的途径。
Acoustofluidic methods, with advantages including simplicity of device design, biocompatible manipulation, and low power consumption, have been touted as promising tools for point-of-care (POC) testing. Here, we report a cell-phone-based acoustofluidic platform that uses acoustic radiation forces to enrich nanoscale analytes and red and green fluorescence nanoparticles (SiO2@R and G@SiO2) as probes for POC visual testing. Thus, the color signals from the fluorescent probes are enhanced, and colorimetric sensitivity is significantly improved. As a POC demonstration, the acoustofluidic platform is used to detect hemoglobin (Hb) from human blood, resulting in a rapid and straightforward measurement of normal blood Hb levels. Combining an acoustofluidic-based nanoparticle-concentration platform with cell-phone-based colorimetry, our method introduces a potential pathway toward practical POC testing.