New boundaries for complement in renal disease
New boundaries for complement in renal disease
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DOI：
10.1681/asn.2007101121
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发表时间：
2008-10-01
影响因子：
13.6
通讯作者：
Zhou, Wuding
中科院分区：
文献类型：
--
作者：
Sacks, Steven;Zhou, Wuding
补体是先天免疫系统的重要组成部分，其功能与适应性免疫反应相结合。由于补体蛋白几乎在体内任何细胞中产生，因此了解哪些补体库负责哪些作用非常重要。对于补体介导的肾脏疾病尤其如此，其中不同的部位可能需要个体化的治疗方法。从迄今为止的实验和临床证据来看，补体循环池似乎是传统上与肾小球疾病相关的大部分病理学的基础，包括毛细血管壁损伤。相反，肾小管间质是补体局部合成的区域，特别是轴向成分C3，主要由肾小管上皮表达。这意味着在某些疾病中，治疗靶向必须确保渗透到间隙空间。同样，对疾病活动的监测可能会受益于评估该血管外池。人类疾病的治疗和诊断应用已经考虑到了这一点，其中移植处于领先地位。
Complement is an important component of the innate immune system whose function is integrated with the adaptive immune response. Since complement proteins are produced in virtually any cell in the body, it is important to question which pools of complement are responsible for what actions. This is particularly so in the case of complement-mediated renal disease, where distinct sites may require individualized approaches for therapy. From experimental and clinical evidence to date, it seems that the circulating pool of complement underlies much of the pathology traditionally associated with glomerular disease, including capillary wall injury. In contrast, the renal tubulointerstitium is the domain of local synthesis of complement, notably the axial component C3, principally expressed by the tubular epithelium. This means that therapeutic targeting will have to ensure penetration of the interstitial space in certain disorders. Likewise, monitoring of disease activity may benefit from evaluating this extravascular pool. Therapeutic and diagnostic applications in human disease are already taking this into account, with transplantation leading the way.