Defective mononuclear cell antibody-dependent cellular cytotoxicity (ADCC) in patients with leukocyte adhesion deficiency emphasizing on different CD11/CD18 requirement of Fc gamma RI versus Fc gamma RII in ADCC.
Defective mononuclear cell antibody-dependent cellular cytotoxicity (ADCC) in patients with leukocyte adhesion deficiency emphasizing on different CD11/CD18 requirement of Fc gamma RI versus Fc gamma RII in ADCC.
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白细胞粘附缺陷患者的缺陷性单核细胞抗体依赖性细胞毒性 (ADCC) 强调 ADCC 中 Fc gamma RI 与 Fc gamma RII 的不同 CD11/CD18 需求。
DOI：
10.1006/cimm.1993.1120
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发表时间：
1993
影响因子：
4.3
通讯作者：
T. Konno
中科院分区：
文献类型：
--
作者：
T. Majima;Y. Ohashi;R. Nagatomi;A. Iizuka;T. Konno
The defective antibody-dependent cellular cytotoxicity (ADCC) of mononuclear cells (MNC) from patients with leukocyte adhesion deficiency (LAD), beta 2 integrins (CD11a-c/CD18) deficiency was shown. LAD patients completely failed to generate MNC-ADCC against sheep red blood cells (SRBC) sensitized with murine (m) IgG2b, but had diminished but significant cytolysis against mIgG2a-SRBC, suggesting that the CD11/CD18 requirement of Fc gamma RI is different from that of Fc gamma RII in MNC-ADCC. Blocking experiments with monoclonal antibodies (mAb) against individual subunits of CD11/CD18 revealed that anti-CD18 mAb almost completely inhibited mIgG2b-mediated ADCC by normal monocytes, but only partially inhibited mIgG2a-mediated ADCC. These data may confirm the evidence that Fc gamma RII-mediated ADCC absolutely requires CD11/CD18 but Fc gamma RI-mediated ADCC does not. Among subunits of CD11/CD18, appeared to be most involved in lysis of sensitized SRBC.
