Inactive Aldehyde Dehydrogenase-2 Increased the Risk of Pancreatic Cancer Among Smokers in a Japanese Male Population
Inactive Aldehyde Dehydrogenase-2 Increased the Risk of Pancreatic Cancer Among Smokers in a Japanese Male Population
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DOI：
10.1097/01.mpa.0000147084.70125.41
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发表时间：
2005-03
期刊：
影响因子：
2.9
通讯作者：
K. Miyasaka;T. Kawanami;H. Shimokata;S. Ohta;A. Funakoshi
中科院分区：
文献类型：
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作者：
K. Miyasaka;T. Kawanami;H. Shimokata;S. Ohta;A. Funakoshi
目的：乙醛是一种公认的动物致癌物，在酒精代谢过程中产生的大部分乙醛被肝脏线粒体乙醛脱氢酶2（ALDH 2）消除。超过40%的日本人有ALDH 2的非活性形式，而非活性ALDH 2是多种食道癌以及头颈癌的风险因素。在日本人群中研究了胰腺癌与ALDH 2基因多态性以及吸烟和/或饮酒习惯之间的可能关联。研究方法：我们调查了114例胰腺癌患者（男性70例，女性44例），并与2070例对照组（男性1050例，女性1020例）进行了比较。检测饮酒量（5 g/d）和/或吸烟习惯以及ALDH 2基因多态性。结果如下：在男性受试者中，胰腺癌患者中ALDH 2活性形式（2*1/2*1）的频率低于对照受试者（P = 0.018）。具有吸烟和饮酒习惯的受试者的频率在胰腺癌患者中显著高于具有ALDH 2 *1/2*1和ALDH 2 *1/2*2的对照受试者。胰腺癌患者中单独吸烟习惯的频率显著高于具有非活性ALDH 2的对照受试者。饮酒习惯与胰腺癌无关。在女性受试者中，这两种习惯都与胰腺癌无关。结论：吸烟习惯确实增加了胰腺癌的风险，并且这种风险在男性人群中而不是女性人群中的非活性ALDH 2受试者中进一步增强。饮酒习惯与胰腺癌在男女人群中均无相关性。
Objectives: Most of the acetaldehyde, a recognized animal carcinogen, generated during alcohol metabolism is eliminated by liver mitochondrial aldehyde dehydrogenase 2 (ALDH2). More than 40% of Japanese have the inactive form of ALDH2, and inactive ALDH2 is a risk factor for multiple cancers of the esophagus as well as head and neck cancer. Possible associations between pancreatic cancer and ALDH2 gene polymorphism, in conjunction with smoking and/or drinking habits, were examined in a Japanese population. Methods: We investigated 114 patients (70 male and 44 female) with pancreatic cancer and compared them with 2070 control subjects (1050 male and 1020 female). The drinking (5 g ethanol consumption/d) and/or smoking habits as well as ALDH2 gene polymorphism were examined. Results: In male subjects, the frequency of the active form of ALDH2 (2*1/2*1) was lower in pancreatic cancer patients than in control subjects (P = 0.018). The frequency of subjects with both smoking and drinking habits was significantly higher in pancreatic cancer patients than in control subjects having ALDH2*1/2*1 and ALDH2*1/2*2. The frequency of smoking habit alone was significantly higher in pancreatic cancer patients compared with control subjects having inactive ALDH2. Drinking habit had no relation to pancreatic cancer. In female subjects, neither habit had a relation to pancreatic cancer. Conclusions: Smoking habit did increase the risk of pancreatic cancer, and this risk was further enhanced in subjects with inactive ALDH2 in a male population but not in a female population. There was no relationship between drinking habit and pancreatic cancer in either sex population.