Mutations in the p53 gene in pulmonary blastomas: Immunohistochemical and molecular studies
Mutations in the p53 gene in pulmonary blastomas: Immunohistochemical and molecular studies
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DOI：
10.1016/s0046-8177(96)90302-0
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发表时间：
1996-11-01
期刊：
影响因子：
3.3
通讯作者：
Koss, MN
中科院分区：
文献类型：
--
作者：
Bodner, SM;Koss, MN
分化良好的胎儿腺癌和双相母细胞瘤是肺癌的类型，其包含模仿胎儿肺外观的腺体。双相母细胞瘤也显示原始胚胎间质。尽管组织学上的相似性导致这两种肿瘤被归类为肺母细胞瘤，但它们具有不同的临床和预后特征。由于这些肿瘤的遗传学改变很少见，因此，作者研究了9例双相母细胞瘤和12例分化良好的胎儿腺癌中p53基因突变的存在。p53基因突变在其他肺癌中很常见，p53基因突变的类型可以提供有关原始或诱发突变的信息。作者通过免疫组化和分子分析发现5例双相母细胞瘤（42%）有p53基因突变，而高分化的胎儿腺癌中没有一例含有突变。这些结果为区分高分化胎儿腺癌和双相母细胞瘤的组织学意义提供了分子支持，并确定了发生在这些肿瘤中的几种类型的p53基因突变。
Well-differentiated fetal adenocarcinomas and biphasic blastomas are types of lung cancer that contain glands that mimic the appearance of fetal lung. Biphasic blastomas also show a primitive embryonic stroma. Despite histological similarities leading these two tumors to be classified as pulmonary blastomas, they have distinct clinical and prognostic features. Little information is available on genetic changes in these tumors because they are rare; therefore, the authors studied nine biphasic blastomas and 12 well-differentiated fetal adenocarcinomas for the presence of mutations in the p53 gene. Mutations in the p53 gene are common in other lung cancers, and the type of mutation in the p53 gene can provide information about the original or inciting mutagens. The authors found five biphasic blastomas (42%) had mutations in the p53 gene by immunohistochemical and molecular analysis, whereas none of the well-differentiated fetal adenocarcinomas contained mutations. These results provide molecular support for the significance of distinguishing between well-differentiated fetal adenocarcinoma and biphasic blastoma histologically and identify several types of p53 gene mutations that occur in these tumors.