Effective inhibition of HCoV-OC43 and SARS-CoV-2 by phytochemicals in vitro and in vivo.
Effective inhibition of HCoV-OC43 and SARS-CoV-2 by phytochemicals in vitro and in vivo.
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DOI：
10.1016/j.ijantimicag.2023.106893
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发表时间：
2023-09
影响因子：
10.8
通讯作者：
Peterson, Karin E.
中科院分区：
文献类型：
--
作者：
Ojha, Durbadal;Jessop, Forrest;Bosio, Catharine M.;Peterson, Karin E.
Several coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus OC43 (HCoV-OC43) can cause respiratory infections in humans. To address the need for reliable anti-coronavirus therapeutics, we screened 16 active phytochemicals selected from medicinal plants used in traditional applications for respiratory-related illnesses. An initial screen was completed using HCoV-OC43. The phytochemicals lycorine (LYC), capsaicin (CAP), rottlerin (RTL), piperine (PIP) and chebulinic acid (CHU) inhibited HCoV-OC43-induced cytopathic effect and reduced viral titers by up to four logs. LYC, RTL and CHU also suppressed virus replication and cell death following SARS-CoV-2 infection. In vivo, RTL significantly reduced SARS-CoV-2-induced mortality by approximately 40% in human ACE2 expressing K18 mice. Collectively, these studies indicate that RTL and other phytochemicals have therapeutic potential to reduce SARS-CoV-2 and HCoV-43 infections.
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